drm
168
phosphopentomutase
locus
BSU_23500
Molecular weight
43.77 kDa
pI
4.97
function
utilization of deoxyribose
product
phosphopentomutase
essential
no
ec
5.4.2.7
synonyms
drm, yqkN
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1015 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,447,246 2,448,430
The protein
Catalyzed reaction/ biological activity
α-D-ribose 1-phosphate --> D-ribose 5-phosphate (according to UniProt)
2-deoxy-α-D-ribose 1-phosphate --> 2-deoxy-D-ribose 5-phosphate (according to UniProt)
Protein family
phosphopentomutase family (single member, according to UniProt)
Structure
[PDB|3M8W] (from ''B. cereus'', 77% identity, 86% similarity) [Pubmed|21193409]
[AF|P46353]
Modification
phosphorylation on (Thr-87 OR Thr-89) [Pubmed|17218307,17726680]
CoA is attached to Cys-233 in spores [pubmed|33206970]
Expression and Regulation
Operons
genes
[gene|9D07E43BF1FFB13CCEAC2B7AAA4EBDFB1079DD74|drm]-[gene|BC6FA7677AAE6BA24530D125007A18056D75DADF|pupG]
description
[Pubmed|10537218]
regulation
induced in the presence of nucleosides (deoxyribose 5-phosphate and ribose 5-phosphate act as molecular inducers) [Pubmed|10537218]
regulatory mechanism
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|22900538], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|10537218], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
BKE23500 ([gene|9D07E43BF1FFB13CCEAC2B7AAA4EBDFB1079DD74|drm]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE23500 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTTGAAAGCCTCCTTTT, downstream forward: _UP4_TAGGGGGACTGTTTCTTGAA
BKK23500 ([gene|9D07E43BF1FFB13CCEAC2B7AAA4EBDFB1079DD74|drm]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK23500 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTTGAAAGCCTCCTTTT, downstream forward: _UP4_TAGGGGGACTGTTTCTTGAA
References
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Time of last update: 2024-12-20 05:23:46
Author of last update: Jstuelk