bmrD
168
multidrug [wiki|ABC transporter ](ATP-binding protein), also involved in the signalling pathway to activate [protein|search|KinA ]at the onset of [wiki|sporulation]
locus
BSU_09720
Molecular weight
76.12 kDa
pI
7.08
function
multiple antibiotic resistance
product
multidrug [wiki|ABC transporter ](ATP-binding protein)
essential
no
synonyms
bmrD, yheH
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1132 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,047,072 1,049,093
The protein
Protein family
[wiki|ABC transporter superfamily] (according to UniProt)
[wiki|Domains]
has both a membrane-spanning and an ATP-binding domain [Pubmed|10092453]
[wiki|ABC transmembrane type-1 domain] (aa 18-398) (according to UniProt)
[wiki|ABC transporter domain] (aa 430-664) (according to UniProt)
Structure
[PDB|7M33] [pubmed|34931066]
[PDB|5MKK] (TmrAB complex from Thermus thermophilus, 38% identity) [pubmed|28069938]
[AF|O07549]
Paralogous protein(s)
[protein|0EB4D3E1B9AF39ECCBD79EB559FAE5BB0EE4C156|ygaD]
[wiki|Localization]
cell membrane [Pubmed|10092453]
Expression and Regulation
Operons
genes
[gene|E9956A958C66C4114EB974EA6F9BF30CD951034A|bmrB]-[gene|E98074149254BF56648F6CBE56E74B3D7DCD5DB3|bmrX]-[gene|67C0C9EA17EF953554D3D57CD0D285246F50C1AD|bmrC]-[gene|9B2766D2F8892AA17DB480216570C81C33355C3B|bmrD]
description
[Pubmed|25217586]
regulation
[gene|E9956A958C66C4114EB974EA6F9BF30CD951034A|bmrB]-[gene|E98074149254BF56648F6CBE56E74B3D7DCD5DB3|bmrX]-[gene|67C0C9EA17EF953554D3D57CD0D285246F50C1AD|bmrC]-[gene|9B2766D2F8892AA17DB480216570C81C33355C3B|bmrD] expression only occurs during the late-exponential and stationary growth stages ([protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB]) [Pubmed|25217586]
RNA processing in the intergenic region between [gene|67C0C9EA17EF953554D3D57CD0D285246F50C1AD|bmrC] and [gene|67C0C9EA17EF953554D3D57CD0D285246F50C1AD|bmrC] (in [gene|E98074149254BF56648F6CBE56E74B3D7DCD5DB3|bmrX]) ([protein|search|Rae1]) [pubmed|37142436]
expression
expression is increased upon depletion of depletion of tRNA maturation factors [gene|57A79AAF00243B5E058FA901D43AA7B55CA33F63|rnpB] or [gene|C40C5D35ED53D343C8200248FCCB010BAB388054|rnz] [pubmed|36840557]
regulatory mechanism
[protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB]: repression, [Pubmed|20817675,25217586], in [regulon|protein:E5110D9C36E8C55AFD1419987B14A53232165F20|abrB regulon]
[protein|E9956A958C66C4114EB974EA6F9BF30CD951034A|bmrB]: attenuation, [Pubmed|25217586], in [regulon|protein:E9956A958C66C4114EB974EA6F9BF30CD951034A|bmrB regulon]
Biological materials
Mutant
MGNA-B491 (yheH::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1490 NBRP B. subtilis, Japan]
BKE09720 ([gene|9B2766D2F8892AA17DB480216570C81C33355C3B|bmrD]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE09720 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TCTCCATAACGTTTTTCCTA, downstream forward: _UP4_TAACGCTCAAAAACCCAAAA
BKK09720 ([gene|9B2766D2F8892AA17DB480216570C81C33355C3B|bmrD]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK09720 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TCTCCATAACGTTTTTCCTA, downstream forward: _UP4_TAACGCTCAAAAACCCAAAA
References
Reviews
Original Publications
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Time of last update: 2024-09-15 17:58:42
Author of last update: Jstuelk