aimB

aimB
168

amino acid permease, minor threonine and serine transporter

locus
BSU_02060
Molecular weight
49.94 kDa
pI
9.6
Protein length
Gene length
function
uptake of threonine and serine
product
amino acid permease
essential
no
synonyms
ybxG, ybdP

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1113 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
226,566  227,954
Phenotypes of a mutant
a [gene|210C83EBEBD3DE4946BC511E0249D0032A7CE3D0|bcaP] [gene|9AD0E43119BDC65D5F67CE55CD9417E1E6BAE058|aimB] mutant confers resistance to 4-hydroxythreonine [pubmed|25777134]
The protein
Catalyzed reaction/ biological activity
uptake of threonine and serine [pubmed|32743959], (symport with H+)
uptake of diaminopropionic acid [pubmed|38470260], (symport with H+)
Protein family
[wiki|amino acid-polyamine-organocation (APC) superfamily] (according to UniProt)
Structure
[PDB|5OQT] (from Geobacillus kaustophilus, 23% identity) [pubmed|29416041]
[AF|P54425]
Paralogous protein(s)
[protein|9BFB16C12B31ABD70BBB921BCB9E4201E3BDC92D|rocC], [protein|B46A8BCEC56E6252712E30F8BF8DA6B836FDE2F6|rocE], [protein|B6A920650919D5BBBD75CCA58C30A0D8ECE64DA3|ybgF], [protein|C7FEA1D9C7C96C39CEE83CE3F13D412DE6AFE10E|ydgF], [protein|CE4A49F5CCC2D36C5CE5AD7AE7F0A70F2D4F425C|aapA], [protein|1594BA83CED2DA9F86C1CE2A0DC6E1C9B665EACB|gabP], [protein|219586A3F378DC38EA076FD39B99D41136BDE722|alaP], [protein|423AEC9D260BE53AD22851D999244B89BEB3E84D|hutM], [protein|8C4A8961B2514A8AD531AFB104B10C0797D02AC2|yvbW]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|9AD0E43119BDC65D5F67CE55CD9417E1E6BAE058|aimB]
description
[pubmed|22383849]
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[gene|9AD0E43119BDC65D5F67CE55CD9417E1E6BAE058|aimB]

2024-09-22 11:34:15

Jstuelk

77

3136cf063460180c735feeb74250539e26db32a8

FA47BAFC26166066F5D5275314FCADFA393CF2CF

Biological materials
Mutant
GP2396 ∆''[gene|9AD0E43119BDC65D5F67CE55CD9417E1E6BAE058|aimB]'' ::''cat'' available in [wiki|Jörg Stülke]'s lab [pubmed|32743959]
BKE02060 (''[gene|9AD0E43119BDC65D5F67CE55CD9417E1E6BAE058|aimB]''::''erm''), available in the BGSC and in [wiki|Fabian Commichau]'s and [wiki|Jörg Stülke]'s labs) [pubmed|28189581]
BKE02060 ([gene|9AD0E43119BDC65D5F67CE55CD9417E1E6BAE058|aimB]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE02060 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CACTCCTCTTCCTCCTCCTA,  downstream forward: _UP4_TAACGATAAAAAAGAGACAT
BKK02060 ([gene|9AD0E43119BDC65D5F67CE55CD9417E1E6BAE058|aimB]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK02060 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CACTCCTCTTCCTCCTCCTA,  downstream forward: _UP4_TAACGATAAAAAAGAGACAT
References
12850135,29416041,25777134,32743959,38470260

9AD0E43119BDC65D5F67CE55CD9417E1E6BAE058

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Time of last update: 2024-10-02 22:54:40

Author of last update: Jstuelk