aimB
168
amino acid permease, minor threonine and serine transporter
locus
BSU_02060
Molecular weight
49.94 kDa
pI
9.6
function
uptake of threonine and serine
product
amino acid permease
essential
no
synonyms
ybxG, ybdP
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1113 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
226,566 227,954
Phenotypes of a mutant
a [gene|210C83EBEBD3DE4946BC511E0249D0032A7CE3D0|bcaP] [gene|9AD0E43119BDC65D5F67CE55CD9417E1E6BAE058|aimB] mutant confers resistance to 4-hydroxythreonine [pubmed|25777134]
The protein
Catalyzed reaction/ biological activity
uptake of threonine and serine [pubmed|32743959], (symport with H+)
uptake of diaminopropionic acid [pubmed|38470260], (symport with H+)
Protein family
[wiki|amino acid-polyamine-organocation (APC) superfamily] (according to UniProt)
Structure
[PDB|5OQT] (from Geobacillus kaustophilus, 23% identity) [pubmed|29416041]
[AF|P54425]
Paralogous protein(s)
[protein|9BFB16C12B31ABD70BBB921BCB9E4201E3BDC92D|rocC], [protein|B46A8BCEC56E6252712E30F8BF8DA6B836FDE2F6|rocE], [protein|B6A920650919D5BBBD75CCA58C30A0D8ECE64DA3|ybgF], [protein|C7FEA1D9C7C96C39CEE83CE3F13D412DE6AFE10E|ydgF], [protein|CE4A49F5CCC2D36C5CE5AD7AE7F0A70F2D4F425C|aapA], [protein|1594BA83CED2DA9F86C1CE2A0DC6E1C9B665EACB|gabP], [protein|219586A3F378DC38EA076FD39B99D41136BDE722|alaP], [protein|423AEC9D260BE53AD22851D999244B89BEB3E84D|hutM], [protein|8C4A8961B2514A8AD531AFB104B10C0797D02AC2|yvbW]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|9AD0E43119BDC65D5F67CE55CD9417E1E6BAE058|aimB]
description
[pubmed|22383849]
Biological materials
Mutant
GP2396 ∆''[gene|9AD0E43119BDC65D5F67CE55CD9417E1E6BAE058|aimB]'' ::''cat'' available in [wiki|Jörg Stülke]'s lab [pubmed|32743959]
BKE02060 (''[gene|9AD0E43119BDC65D5F67CE55CD9417E1E6BAE058|aimB]''::''erm''), available in the BGSC and in [wiki|Fabian Commichau]'s and [wiki|Jörg Stülke]'s labs) [pubmed|28189581]
BKE02060 ([gene|9AD0E43119BDC65D5F67CE55CD9417E1E6BAE058|aimB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE02060 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACTCCTCTTCCTCCTCCTA, downstream forward: _UP4_TAACGATAAAAAAGAGACAT
BKK02060 ([gene|9AD0E43119BDC65D5F67CE55CD9417E1E6BAE058|aimB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK02060 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACTCCTCTTCCTCCTCCTA, downstream forward: _UP4_TAACGATAAAAAAGAGACAT
References
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Time of last update: 2024-12-22 08:12:23
Author of last update: Jstuelk