spo0F
168
phosphotransferase of the [wiki|sporulation] initiation [wiki|phosphorelay]
locus
BSU_37130
Molecular weight
14.09 kDa
pI
4.7
function
initiation of [wiki|sporulation]
product
phosphotransferase of the sporulation initiation phosphorelay
essential
no
synonyms
spo0F
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG5803 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,809,550 3,809,924
The protein
[wiki|Domains]
[wiki|Response regulatory domain] (aa 5-119) (according to UniProt)
Structure
[PDB|1SRR] (phosphatase resistant mutant)
[PDB|1F51] (complex with [protein|29D91115BB3AC03538D618E54A5A57F92777EFF6|spo0B])
[PDB|2JVK] (Mutant L66A),
[PDB|2FSP]
[PDB|3Q15] ([protein|BA85E2C2E2A6B76FAFA31EBDBF466324C9B021C8|rapH]-[protein|9896B99346B0D3F6D57F57377DB253B46135A37A|spo0F] complex) [Pubmed|21346797]
[AF|P06628]
Modification
phosphorylated on an Asp residue by [protein|B29CAD04FB89ACC482EFCD29D50EDDA19145CAA2|kinA], [protein|2111AC1AE49D1006E10DC127BF5B7A0327DE94A7|kinB], [protein|A656321846B2E0D1F39B528E2D8B8E620CCD1148|kinC], [protein|511E71BB1981758857854C8E9BF657287CE60C11|kinD], or [protein|1582E81F7DA85F38D6732D341ABD0F052587F25A|kinE]
dephosphorylated by [protein|25D89EF3C4D57B3E6F9AB0210029651F74356906|rapA], [protein|E07E123CC9FB3B29DDA8EC58A33FEEE1DDFC4834|rapB], [protein|8B8646DF7F437D8DB299A77BA937DC6FC082102F|rapE], or [protein|BA85E2C2E2A6B76FAFA31EBDBF466324C9B021C8|rapH] [Pubmed|17581123]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|9896B99346B0D3F6D57F57377DB253B46135A37A|spo0F]
description
[Pubmed|2457578]
regulation
expressed under conditions that trigger sporulation ([wiki|Spo0A]) [Pubmed|8483422]
regulatory mechanism
[protein|2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A]: activation, [Pubmed|8483422], in [regulon|protein:2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|2457578], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
[protein|DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|sigH]: sigma factor, [Pubmed|1569009], in [regulon|protein:DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|sigH regulon]
Biological materials
Mutant
BKE37130 ([gene|9896B99346B0D3F6D57F57377DB253B46135A37A|spo0F]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE37130 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTTACACCCCAATATTA, downstream forward: _UP4_TGACAAAAAGAAGAAACAAA
BKK37130 ([gene|9896B99346B0D3F6D57F57377DB253B46135A37A|spo0F]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK37130 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTTACACCCCAATATTA, downstream forward: _UP4_TGACAAAAAGAAGAAACAAA
References
Reviews
Original Publications
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Time of last update: 2024-10-07 16:55:56
Author of last update: Jstuelk