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psdR
168
two-component response regulator ([wiki|OmpR family]), induction of [gene|464DD1855E6B3195EE242637612A16C73FF32FC0|psdA]-[gene|AC7F08DC1DF7DD2F9AFF84041D357B286B1244AC|psdB] in response to lipid II-binding lantibiotics (nisin and gallidermin) and internal antimicrobial peptides ([protein|820635420B3980B620F3E3D7ACF7EDE9DC6275AD|sdpC], [protein|DDB0022F50999AC52809D651C9CC5A5FDC71302C|skfA])
Molecular weight
27.37 kDa
function
resistance against toxic peptides
product
two-component response regulator ([wiki|OmpR family])
Genomic Context
This gene is a member of the following
regulons
Gene
Coordinates
3,567,422 3,568,135
The protein
Protein family
[wiki|OmpR family] of two-component response regulators
[wiki|Domains]
[wiki|Response regulatory domain] (aa 3-116) (according to UniProt)
Structure
[PDB|5DCL] (from Streptococcus agalactiae, 42% identity) [pubmed|26930060]
[AF|O06978]
Modification
phosphorylated by [protein|A9525886E911164BDFF0A55DA9F5FDD1C1B7A3B6|psdS] on an Asp residue
Effectors of protein activity
phosphorylation likely affects DNA-binding activity
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|985E7F25C809AA5DF372101E64960DF704EED53F|psdR]-[gene|A9525886E911164BDFF0A55DA9F5FDD1C1B7A3B6|psdS]-[gene|464DD1855E6B3195EE242637612A16C73FF32FC0|psdA]-[gene|AC7F08DC1DF7DD2F9AFF84041D357B286B1244AC|psdB]
description
[Pubmed|21078927]
regulation
''[protein|search|psdA]'': induced by nisin, gallidermin ([protein|search|PsdR]) [Pubmed|21078927]
regulatory mechanism
[protein|985E7F25C809AA5DF372101E64960DF704EED53F|psdR]: activation, [Pubmed|21078927], in [regulon|protein:985E7F25C809AA5DF372101E64960DF704EED53F|psdR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|21078927], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
[gene|985E7F25C809AA5DF372101E64960DF704EED53F|psdR]→[gene|AC7F08DC1DF7DD2F9AFF84041D357B286B1244AC|psdB]
2024-09-17 19:13:02
ghost
54
d7c5e7b0711e6228a3cdf2a71273ad8f725b7c09
5FD7CD564F41C61165A1333E78C1CCE35B7CF017
Biological materials
Mutant
MGNA-B637 (yvcP::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1636 NBRP B. subtilis, Japan]
BKE34720 ([gene|985E7F25C809AA5DF372101E64960DF704EED53F|psdR]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE34720 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACGTTGATCCCCCTTATAT, downstream forward: _UP4_GTCAATCGGAAGGATGAAGC
BKK34720 ([gene|985E7F25C809AA5DF372101E64960DF704EED53F|psdR]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK34720 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACGTTGATCCCCCTTATAT, downstream forward: _UP4_GTCAATCGGAAGGATGAAGC
References
Reviews
Original Publications
10094672,18394148,14651641,21283517,23504016,21078927,26364265,27188294,27997719,26930060
