resC

resC
168

part of heam translocase, required for cytochrome c synthesis

locus
BSU_23130
Molecular weight
39.61 kDa
pI
9.56
Protein length
Gene length
function
cytochrome c biogenesis
product
part of the [protein|495721E4B8BF6FEC01E62E86339560F90776EED1|resB]-[protein|97FE84CF968596AC39D19EE2E43DA625147FD702|resC] haem translocase
essential
no
synonyms
resC, ypxC

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0755 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,417,984  2,419,159
Phenotypes of a mutant
essential [Pubmed|12682299], non-essential according to [Pubmed|28189581]
The protein
Catalyzed reaction/ biological activity
haem-binding protein,  translocation of haem from the cytoplasmic to the extracytoplasmic site of the membrane [Pubmed|19682263]
Protein family
CcmF/CycK/Ccl1/NrfE/CcsA family (single member, according to UniProt)
Structure
[AF|P35162]
[wiki|Localization]
cytoplasma membrane [Pubmed|19682263]
Expression and Regulation
Operons
genes
[gene|5CD1E266B0EC82546A2AF19A05490DD4D04F812C|rluB]-[gene|F7D869F77E2275110737EF658C58FA1BF742D73F|resA]-[gene|495721E4B8BF6FEC01E62E86339560F90776EED1|resB]-[gene|97FE84CF968596AC39D19EE2E43DA625147FD702|resC]-[gene|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]-[gene|EA6790EF30D3DDB9670FE52DFD2C5083AB6A48E1|resE]
description
[Pubmed|22383849]
Open in new tab

[gene|5CD1E266B0EC82546A2AF19A05490DD4D04F812C|rluB]→[gene|A44D4677FB70BE8F554BF1001A500F817C7DA95F|recA]

2024-12-04 16:25:51

Jstuelk

91

810e88212899b5da40206112287802e7d6377a71

48F6784365F7D14D1F54674DD0C766FFA75949EC

genes
[gene|F7D869F77E2275110737EF658C58FA1BF742D73F|resA]-[gene|495721E4B8BF6FEC01E62E86339560F90776EED1|resB]-[gene|97FE84CF968596AC39D19EE2E43DA625147FD702|resC]-[gene|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]-[gene|EA6790EF30D3DDB9670FE52DFD2C5083AB6A48E1|resE]
description
[Pubmed|8631715]
regulation
expressed under anaerobic conditions ([protein|search|ResD]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8631715,11222591 PubMed]
regulatory mechanism
[protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]: activation, [PubMed|8631715,11222591], in [regulon|protein:1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD regulon]
[protein|638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|phoP]: activation, [Pubmed|9988472], in [regulon|protein:638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|phoP regulon]
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|16825793], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8631715], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Open in new tab

[gene|F7D869F77E2275110737EF658C58FA1BF742D73F|resA]→[gene|EA6790EF30D3DDB9670FE52DFD2C5083AB6A48E1|resE]

2024-11-05 03:38:38

ghost

87

35cf88192088e7d30495dfc1ae6639ee89ad31fe

7099FE353EE3AD6D60FB99016C9CE5D3AB2282C2

Biological materials
Mutant
BKE23130 ([gene|97FE84CF968596AC39D19EE2E43DA625147FD702|resC]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE23130 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_TGCCATGACATCACTCCCTT,  downstream forward: _UP4_TAGTCCTTTGAAAGCGACAC
BKK23130 ([gene|97FE84CF968596AC39D19EE2E43DA625147FD702|resC]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK23130 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_TGCCATGACATCACTCCCTT,  downstream forward: _UP4_TAGTCCTTTGAAAGCGACAC
References
Reviews
35630371
Original Publications
10844653,19682263,8631715,11222591,9988472,17706591,16825793,28189581,36815589

97FE84CF968596AC39D19EE2E43DA625147FD702

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Time of last update: 2024-12-05 21:42:37

Author of last update: Jstuelk