resC
168
part of heam translocase, required for cytochrome c synthesis
locus
BSU_23130
Molecular weight
39.61 kDa
pI
9.56
function
cytochrome c biogenesis
product
part of the [protein|495721E4B8BF6FEC01E62E86339560F90776EED1|resB]-[protein|97FE84CF968596AC39D19EE2E43DA625147FD702|resC] haem translocase
essential
no
synonyms
resC, ypxC
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0755 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,417,984 2,419,159
Phenotypes of a mutant
essential [Pubmed|12682299], non-essential according to [Pubmed|28189581]
The protein
Catalyzed reaction/ biological activity
haem-binding protein, translocation of haem from the cytoplasmic to the extracytoplasmic site of the membrane [Pubmed|19682263]
Protein family
CcmF/CycK/Ccl1/NrfE/CcsA family (single member, according to UniProt)
Structure
[AF|P35162]
[wiki|Localization]
cytoplasma membrane [Pubmed|19682263]
Expression and Regulation
Operons
genes
[gene|5CD1E266B0EC82546A2AF19A05490DD4D04F812C|rluB]-[gene|F7D869F77E2275110737EF658C58FA1BF742D73F|resA]-[gene|495721E4B8BF6FEC01E62E86339560F90776EED1|resB]-[gene|97FE84CF968596AC39D19EE2E43DA625147FD702|resC]-[gene|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]-[gene|EA6790EF30D3DDB9670FE52DFD2C5083AB6A48E1|resE]
description
[Pubmed|22383849]
genes
[gene|F7D869F77E2275110737EF658C58FA1BF742D73F|resA]-[gene|495721E4B8BF6FEC01E62E86339560F90776EED1|resB]-[gene|97FE84CF968596AC39D19EE2E43DA625147FD702|resC]-[gene|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]-[gene|EA6790EF30D3DDB9670FE52DFD2C5083AB6A48E1|resE]
description
[Pubmed|8631715]
regulation
expressed under anaerobic conditions ([protein|search|ResD]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8631715,11222591 PubMed]
regulatory mechanism
[protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]: activation, [PubMed|8631715,11222591], in [regulon|protein:1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD regulon]
[protein|638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|phoP]: activation, [Pubmed|9988472], in [regulon|protein:638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|phoP regulon]
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|16825793], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8631715], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
BKE23130 ([gene|97FE84CF968596AC39D19EE2E43DA625147FD702|resC]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE23130 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TGCCATGACATCACTCCCTT, downstream forward: _UP4_TAGTCCTTTGAAAGCGACAC
BKK23130 ([gene|97FE84CF968596AC39D19EE2E43DA625147FD702|resC]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK23130 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TGCCATGACATCACTCCCTT, downstream forward: _UP4_TAGTCCTTTGAAAGCGACAC
References
Reviews
Original Publications
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Time of last update: 2024-12-20 20:57:42
Author of last update: Jstuelk