dctR
168
two-component response regulator, regulation of the [gene|9A96572B101358768EB20EE9438BE0E1424A4130|dctS]-[gene|97C34F6FA0B89D93369150E9A8AB3579332B07BC|dctR]-[gene|search|dctP ]operon
locus
BSU_04460
Molecular weight
25.39 kDa
pI
8.6
function
regulation of the [gene|9A96572B101358768EB20EE9438BE0E1424A4130|dctS]-[gene|97C34F6FA0B89D93369150E9A8AB3579332B07BC|dctR]-[gene|search|dctP ]operon
product
two-component response regulator
essential
no
synonyms
dctR, ydbG
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG4565 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
499,365 500,045
The protein
[wiki|Domains]
[wiki|Response regulatory domain] (aa 7-123) (according to UniProt)
Structure
[PDB|4HYE] (Spr1814 from Streptococcus pneumoniae, 30% identity) [pubmed|23545256]
[AF|P96602]
Modification
phosphorylated by [protein|9A96572B101358768EB20EE9438BE0E1424A4130|dctS] on an Asp residue
Effectors of protein activity
phosphorylation likely affects DNA-binding activity
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|9A96572B101358768EB20EE9438BE0E1424A4130|dctS]-[gene|97C34F6FA0B89D93369150E9A8AB3579332B07BC|dctR]-[gene|107DDCC7B6AA2D7CB02E53F043A93CF05C679081|dctP]
description
[Pubmed|10708364]
regulation
part of the iron sparing response, strong down-regulation in a'' [protein|search|fur]'' mutant ([protein|search|Fur], [protein|search|FsrA]) [Pubmed|22389480]
Biological materials
Mutant
BKE04460 ([gene|97C34F6FA0B89D93369150E9A8AB3579332B07BC|dctR]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE04460 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTCAATGAGCAGAACCTTCC, downstream forward: _UP4_TAAACCTGAGACCAAAAAGA
BKK04460 ([gene|97C34F6FA0B89D93369150E9A8AB3579332B07BC|dctR]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK04460 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTCAATGAGCAGAACCTTCC, downstream forward: _UP4_TAAACCTGAGACCAAAAAGA
References
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Time of last update: 2024-12-20 17:08:01
Author of last update: Melvin.boenninger