aroF

aroF
168

chorismate synthase

locus
BSU_22710
Molecular weight
40.04 kDa
pI
6.58
Protein length
Gene length
function
biosynthesis of aromatic amino acids
product
chorismate synthase
essential
yes
ec
4.2.3.5
synonyms
aroF

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0082 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,379,100  2,380,272
Phenotypes of a mutant
essential [Pubmed|28189581]
The protein
Catalyzed reaction/ biological activity
5-O-(1-carboxyvinyl)-3-phosphoshikimate --> chorismate + phosphate (according to UniProt)
Protein family
chorismate synthase family (single member, according to UniProt)
[wiki|Cofactors]
FAD (according to UniProt)
Structure
[PDB|2O11] (from ''Mycobacterium tuberculosis h37rv mutant'', 42% identity, 58% similarity)
[AF|P31104]
Modification
phosphorylated on Arg-127 [Pubmed|22517742]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|1217807AE3AE3A654BA0DD4AF5ADF1CEE62632B6|cheR]-[gene|9712D0E655289C97315314BDEE1A0DF2ED2ADCA2|aroF]-[gene|58B782C1F7931F8671161455E65E3D5C72B0BB9C|aroB]-[gene|5C2F7F9F5FCBFEDF77AC41725EFDA0FAF0FC3BC1|aroH]
description
[pubmed|22383849]
Open in new tab

[gene|1217807AE3AE3A654BA0DD4AF5ADF1CEE62632B6|cheR]→[gene|5C2F7F9F5FCBFEDF77AC41725EFDA0FAF0FC3BC1|aroH]

2024-09-25 01:32:25

Jstuelk

126

88965d20d1da4832592c311cace3ecbf90c44644

85AFABBE9DF5093CCB38A8A7CAF16B0DE8C014A7

genes
[gene|9712D0E655289C97315314BDEE1A0DF2ED2ADCA2|aroF]-[gene|58B782C1F7931F8671161455E65E3D5C72B0BB9C|aroB]-[gene|5C2F7F9F5FCBFEDF77AC41725EFDA0FAF0FC3BC1|aroH]
description
[pubmed|21815947]
Open in new tab

[gene|9712D0E655289C97315314BDEE1A0DF2ED2ADCA2|aroF]→[gene|5C2F7F9F5FCBFEDF77AC41725EFDA0FAF0FC3BC1|aroH]

2024-09-28 16:53:08

Jstuelk

61

11ded187035e045106d8194f04674749e2b39e61

BB6AEFA38C0BE93441F72C5C4A7B99691660ECBA

Biological materials
Mutant
BKE22710 ([gene|9712D0E655289C97315314BDEE1A0DF2ED2ADCA2|aroF]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE22710 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGACTTCTTCTCCCTTCA,  downstream forward: _UP4_AGAAAACTGTCGAGGGAATT
References
Reviews
12966138
Original Publications
4202998,22517742,28189581,21815947

9712D0E655289C97315314BDEE1A0DF2ED2ADCA2

Page visits: 3122

Time of last update: 2024-10-03 09:02:29

Author of last update: Melvin.boenninger