aroF
168
chorismate synthase
locus
BSU_22710
Molecular weight
40.04 kDa
pI
6.58
function
biosynthesis of aromatic amino acids
product
chorismate synthase
essential
yes
ec
4.2.3.5
synonyms
aroF
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0082 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,379,100 2,380,272
Phenotypes of a mutant
essential [Pubmed|28189581]
The protein
Catalyzed reaction/ biological activity
5-O-(1-carboxyvinyl)-3-phosphoshikimate --> chorismate + phosphate (according to UniProt)
Protein family
chorismate synthase family (single member, according to UniProt)
[wiki|Cofactors]
FAD (according to UniProt)
Structure
[PDB|2O11] (from ''Mycobacterium tuberculosis h37rv mutant'', 42% identity, 58% similarity)
[AF|P31104]
Modification
phosphorylated on Arg-127 [Pubmed|22517742]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|1217807AE3AE3A654BA0DD4AF5ADF1CEE62632B6|cheR]-[gene|9712D0E655289C97315314BDEE1A0DF2ED2ADCA2|aroF]-[gene|58B782C1F7931F8671161455E65E3D5C72B0BB9C|aroB]-[gene|5C2F7F9F5FCBFEDF77AC41725EFDA0FAF0FC3BC1|aroH]
description
[pubmed|22383849]
genes
[gene|9712D0E655289C97315314BDEE1A0DF2ED2ADCA2|aroF]-[gene|58B782C1F7931F8671161455E65E3D5C72B0BB9C|aroB]-[gene|5C2F7F9F5FCBFEDF77AC41725EFDA0FAF0FC3BC1|aroH]
description
[pubmed|21815947]
Biological materials
Mutant
BKE22710 ([gene|9712D0E655289C97315314BDEE1A0DF2ED2ADCA2|aroF]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE22710 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGACTTCTTCTCCCTTCA, downstream forward: _UP4_AGAAAACTGTCGAGGGAATT
References
Reviews
Original Publications
Page visits: 3286
Time of last update: 2024-12-28 20:46:53
Author of last update: Melvin.boenninger