yvrG
168
two-component sensor kinase of the YvrG-YvrHb two-component system
locus
BSU_33210
Molecular weight
66.58 kDa
pI
9.52
function
regulation cell surface maintenance
product
two-component sensor histidine kinase
essential
no
ec
null
synonyms
yvrG
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0642 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,406,614 3,408,356
Phenotypes of a mutant
unusual autolysis and higher susceptibility to cell envelope antibiotics (bacitracin, aztreonam, cefepime, fosfomycin) [Pubmed|16306698]
The protein
Catalyzed reaction/ biological activity
autophosphorylation, phosphorylation of the [protein|7098319D8E88FDC2A629A3F4A21507FD7A649385|yvrHb] response regulator [Pubmed|16306698]
ATP + protein L-histidine --> ADP + protein N-phospho-L-histidine (according to UniProt)
[wiki|Domains]
two transmembrane segments
[wiki|Histidine kinase domain] (aa 363-580) (according to UniProt)
Structure
[AF|O34989]
Modification
autophosphorylation on a His residue
Paralogous protein(s)
[protein|9E8A6AB3920BFBFDAAD1F2E4F333A32354ABB25B|ykoH], [protein|1582E81F7DA85F38D6732D341ABD0F052587F25A|kinE], [protein|4EE48E4931F662E51586DB6D01E91C688329222D|cssS], [protein|52BB660B0CAB36C74F1D47963235846B45AF78AB|yclK]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|7098319D8E88FDC2A629A3F4A21507FD7A649385|yvrHb]-[gene|96E4470EF4B558F4EC318FEBF58B779BA50DB7E2|yvrG]-[gene|0F65F634368E935585FC015BA64085F3A2244F9B|yvrE]
description
[Pubmed|22383849]
Biological materials
Mutant
MGNA-B049 (yvrG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1048 NBRP B. subtilis, Japan]
BKE33210 ([gene|96E4470EF4B558F4EC318FEBF58B779BA50DB7E2|yvrG]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE33210 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CCTCATGACCGCTTGCCTTC, downstream forward: _UP4_TAAACATCAAGTGGTTTGGA
BKK33210 ([gene|96E4470EF4B558F4EC318FEBF58B779BA50DB7E2|yvrG]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK33210 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CCTCATGACCGCTTGCCTTC, downstream forward: _UP4_TAAACATCAAGTGGTTTGGA
References
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Time of last update: 2025-01-02 15:15:23
Author of last update: Melvin.boenninger