tsf
168
elongation factor Ts, nucleotide exchange factor for EF-Tu
locus
BSU_16500
Molecular weight
32.00 kDa
pI
4
function
translation
product
elongation factor Ts
essential
yes
synonyms
tsf
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0264 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,718,775 1,719,656
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
nucleotide exchange factor for EF-Tu [pubmed|12932732,20025795]
Protein family
EF-Ts family (single member, according to UniProt)
Structure
[PDB|1EFU] (the [protein|94E1130A787CBCCCDBDA93C8AFC24ECB82D5FE61|tsf]-[protein|E771685D6D41D48E0C0AF77F15B4F380820FCDC2|tufA] complex from ''E. coli'', 50% identity) [Pubmed|8596629]
[AF|P80700]
Modification
phosphorylation on Ser-149 [Pubmed|17218307]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Additional information
belongs to the 100 most abundant proteins [PubMed|15378759]
Expression and Regulation
Operons
genes
[gene|F1969E4C7BAAF70BCBE570F58350C12A3E417539|rpsB]-[gene|94E1130A787CBCCCDBDA93C8AFC24ECB82D5FE61|tsf]-[gene|40655595D0C573B4CB75FB255CBB01A6ACF1F94D|pyrH]-[gene|093960C48AD50C0D0B3A68BBFE7D060BE716935D|frr]
description
[pubmed|22383849]
regulation
[protein|CEE73284EFC0DBE8870CE0B474922DED79475A57|rel] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
regulatory mechanism
stringent response: negative regulation, [pubmed|11948165], in [regulon|other_regulator:stringent response|stringent response]
References
Reviews
Original Publications
Page visits: 3807
Time of last update: 2024-12-20 20:05:12
Author of last update: Jstuelk