tcyB

tcyB
168

cystine and diaminopimelate [wiki|ABC transporter] (permease)

locus
BSU_03600
Molecular weight
26.24 kDa
pI
9.93
Protein length
Gene length
function
cystine and diaminopimelate uptake
product
cystine and diaminopimelate [wiki|ABC transporter] (permease), membrane protein
essential
no
synonyms
tcyB, yckJ

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0765 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
409,965  410,669
The protein
Catalyzed reaction/ biological activity
uptake of cystine and diaminopimelate [pubmed|29995990]
Protein family
[wiki|Binding-protein-dependent transport system permease family] (according to UniProt)
Structure
[PDB|4YMS] (amino acid transporter from Caldanaerobacter subterraneus, 37% identity) [pubmed|25848002]
[AF|P42200]
Paralogous protein(s)
[protein|FFD5F07480A0E5A74852C69C436EE289BA72FC7F|yxeN], [protein|1872614A6F7DBF7231348AC3DAE4ED3295ACEB41|yckA]
[wiki|Localization]
membrane protein [Pubmed|10092453,18763711]
Expression and Regulation
Operons
genes
[gene|2056F8EEDF9D3027CFD808E8D0C5DF544DBDD3F3|tcyA]-[gene|9400DF25487461E3738DDDC72BDDB1589281409D|tcyB]-[gene|B453986691E1231A1C565D469A2A60EBFF2F6BD3|tcyC]
description
[Pubmed|22383849,15262924]
regulation
strongly repressed in response to glucose starvation in M9 medium [Pubmed|23033921]
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[gene|2056F8EEDF9D3027CFD808E8D0C5DF544DBDD3F3|tcyA]→[gene|B453986691E1231A1C565D469A2A60EBFF2F6BD3|tcyC]

2024-10-10 05:24:26

Jstuelk

105

4d611b63f86c92d9ecb8c2daaa53e692acd195f5

768128284DD011A0C571EBC11696DA21513C3B17

Biological materials
Mutant
MGNA-C059 (yckJ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2057 NBRP B. subtilis, Japan]
BKE03600 ([gene|9400DF25487461E3738DDDC72BDDB1589281409D|tcyB]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE03600 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CGTGCCAAGCGTCAATGCCG,  downstream forward: _UP4_GTGGCCAAATAAGGAGGTTC
BKK03600 ([gene|9400DF25487461E3738DDDC72BDDB1589281409D|tcyB]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK03600 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CGTGCCAAGCGTCAATGCCG,  downstream forward: _UP4_GTGGCCAAATAAGGAGGTTC
References
15262924,10092453,7551042,18763711,25848002,29995990

9400DF25487461E3738DDDC72BDDB1589281409D

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Time of last update: 2024-10-12 17:09:39

Author of last update: Jstuelk