tcyB
168
[metabolite|cystine] and [metabolite|diaminopimelate] [wiki|ABC transporter] (permease)
locus
BSU_03600
Molecular weight
26.24 kDa
pI
9.93
function
[metabolite|cystine] and [metabolite|diaminopimelate] uptake
product
[metabolite|cystine] and [metabolite|diaminopimelate] [wiki|ABC transporter] (permease), membrane protein
essential
no
synonyms
tcyB, yckJ
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0765 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
409,965 410,669
The protein
Catalyzed reaction/ biological activity
uptake of cystine and diaminopimelate [pubmed|29995990]
Protein family
[wiki|Binding-protein-dependent transport system permease family] (according to UniProt)
Structure
[PDB|4YMS] (amino acid transporter from Caldanaerobacter subterraneus, 37% identity) [pubmed|25848002]
[AF|P42200]
Paralogous protein(s)
[protein|FFD5F07480A0E5A74852C69C436EE289BA72FC7F|yxeN], [protein|1872614A6F7DBF7231348AC3DAE4ED3295ACEB41|yckA]
[wiki|Localization]
membrane protein [Pubmed|10092453,18763711]
Expression and Regulation
Operons
genes
[gene|2056F8EEDF9D3027CFD808E8D0C5DF544DBDD3F3|tcyA]-[gene|9400DF25487461E3738DDDC72BDDB1589281409D|tcyB]-[gene|B453986691E1231A1C565D469A2A60EBFF2F6BD3|tcyC]
description
[Pubmed|22383849,15262924]
regulation
strongly repressed in response to glucose starvation in M9 medium [Pubmed|23033921]
Biological materials
Mutant
MGNA-C059 (yckJ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2057 NBRP B. subtilis, Japan]
BKE03600 ([gene|9400DF25487461E3738DDDC72BDDB1589281409D|tcyB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE03600 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CGTGCCAAGCGTCAATGCCG, downstream forward: _UP4_GTGGCCAAATAAGGAGGTTC
BKK03600 ([gene|9400DF25487461E3738DDDC72BDDB1589281409D|tcyB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK03600 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CGTGCCAAGCGTCAATGCCG, downstream forward: _UP4_GTGGCCAAATAAGGAGGTTC
References
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Time of last update: 2024-12-21 22:13:14
Author of last update: Jstuelk