yhcA

yhcA
168

c-di-AMP exporter

locus
BSU_09010
Molecular weight
58.17 kDa
pI
9.49
Protein length
Gene length
function
secretion of cyclic di-AMP
product
c-di-AMP exporter
essential
no
synonyms
yhcA

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2814 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
977,775  979,373
The protein
Catalyzed reaction/ biological activity
secretion of cyclic di-AMP [pubmed|29588402]
Protein family
[wiki|major facilitator superfamily] (according to UniProt)
[wiki|EmrB family] (according to UniProt)
Structure
[PDB|6E8J] (from Hyphomonas neptunium, corresponds to aa 93 ... 204, 28% identity)
[AF|P54585]
Paralogous protein(s)
[protein|188742B9A0C95344D32A4C23B9C971660572CF7D|ycnB], [protein|23483430AE0381406EF2349A18CFAE1F14F9B180|lmrB]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|EDDD61CF725449E57C72F63D378F6CD1FAC49ADA|yhbI]-[gene|211C58A92BA2A06A34B1F73BDB68A0F581B942C2|yhbJ]-[gene|93159DC7D5C42CFA54F66F232D73F38957243AB7|yhcA]-[gene|7797B0B66922D51B9D142DD2E5857836E47F015B|yhcB]-[gene|95EED3A91483502CA78067421F678B1EDB965B18|yhcC]
description
[Pubmed|22383849]
additional information
the mRNA is substantially stabilized upon depletion of [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] (the half-life of the mRNA increases from 4 to 41 min) [PubMed|21815947]
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[gene|EDDD61CF725449E57C72F63D378F6CD1FAC49ADA|yhbI]→[gene|95EED3A91483502CA78067421F678B1EDB965B18|yhcC]

2024-12-21 14:09:56

Jstuelk

58

65b8eed6f6195e33988a759b72502a718556f155

51EDE59EF3FA1E0885DE1370B2F6E6D734862A76

Biological materials
Mutant
MGNA-B471 (yhcA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1470 NBRP B. subtilis, Japan]
GP1704 (''[gene|93159DC7D5C42CFA54F66F232D73F38957243AB7|yhcA]''::''ermC'', without terminator), available in [wiki|Jörg Stülke]'s lab
BKE09010 ([gene|93159DC7D5C42CFA54F66F232D73F38957243AB7|yhcA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE09010 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATCTAAGACAACCTCCTTT,  downstream forward: _UP4_TAATCTGTACAGGGAGGTTT
BKK09010 ([gene|93159DC7D5C42CFA54F66F232D73F38957243AB7|yhcA]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK09010 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATCTAAGACAACCTCCTTT,  downstream forward: _UP4_TAATCTGTACAGGGAGGTTT
References
21815947,29588402

93159DC7D5C42CFA54F66F232D73F38957243AB7

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Time of last update: 2024-12-18 10:54:06

Author of last update: Jstuelk