yhcA
168
c-di-AMP exporter
locus
BSU_09010
Molecular weight
58.17 kDa
pI
9.49
function
secretion of cyclic di-AMP
product
c-di-AMP exporter
essential
no
synonyms
yhcA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG2814 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
977,775 979,373
The protein
Catalyzed reaction/ biological activity
secretion of cyclic di-AMP [pubmed|29588402]
Protein family
[wiki|major facilitator superfamily] (according to UniProt)
[wiki|EmrB family] (according to UniProt)
Structure
[PDB|6E8J] (from Hyphomonas neptunium, corresponds to aa 93 ... 204, 28% identity)
[AF|P54585]
Paralogous protein(s)
[protein|188742B9A0C95344D32A4C23B9C971660572CF7D|ycnB], [protein|23483430AE0381406EF2349A18CFAE1F14F9B180|lmrB]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|EDDD61CF725449E57C72F63D378F6CD1FAC49ADA|yhbI]-[gene|211C58A92BA2A06A34B1F73BDB68A0F581B942C2|yhbJ]-[gene|93159DC7D5C42CFA54F66F232D73F38957243AB7|yhcA]-[gene|7797B0B66922D51B9D142DD2E5857836E47F015B|yhcB]-[gene|95EED3A91483502CA78067421F678B1EDB965B18|yhcC]
description
[Pubmed|22383849]
additional information
the mRNA is substantially stabilized upon depletion of [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] (the half-life of the mRNA increases from 4 to 41 min) [PubMed|21815947]
Biological materials
Mutant
MGNA-B471 (yhcA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1470 NBRP B. subtilis, Japan]
GP1704 (''[gene|93159DC7D5C42CFA54F66F232D73F38957243AB7|yhcA]''::''ermC'', without terminator), available in [wiki|Jörg Stülke]'s lab
BKE09010 ([gene|93159DC7D5C42CFA54F66F232D73F38957243AB7|yhcA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE09010 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTAAGACAACCTCCTTT, downstream forward: _UP4_TAATCTGTACAGGGAGGTTT
BKK09010 ([gene|93159DC7D5C42CFA54F66F232D73F38957243AB7|yhcA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK09010 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTAAGACAACCTCCTTT, downstream forward: _UP4_TAATCTGTACAGGGAGGTTT
References
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Time of last update: 2024-10-06 12:26:11
Author of last update: Jstuelk