fosB
168
bacillithiol-S-transferase; confers resistence against antimicrobial compounds from B. amyloliquefaciens
locus
BSU_17840
Molecular weight
17.03 kDa
pI
6.14
function
confers resistence against antimicrobial compounds from B. amyloliquefaciens
product
fosfomycin resistance protein
essential
no
synonyms
fosB, yndN
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0346 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,916,663 1,917,097
Phenotypes of a mutant
sensitive to fosfomycin [pubmed|11244082]
The protein
Protein family
fosfomycin resistance protein family (single member, according to UniProt)
[wiki|Domains]
[wiki|VOC domain] (aa 5-120) (according to UniProt)
[wiki|Cofactors]
Mg2+ [pubmed|11244082]
Structure
[PDB|4JD1] (from B. anthracis, 66% identity)
[AF|O31817]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|92E4F908B7CDE64743796CCD3188FE6BB5288365|fosB]
description
[Pubmed|11244082]
regulation
expressed under stress conditions ([protein|search|SigW]) [Pubmed|11244082]
sigma factors
[protein|3D974DD2967C7F8FD4E3C2AF42617B8AE9F0296D|sigW]: sigma factor, [Pubmed|11244082], in [regulon|protein:3D974DD2967C7F8FD4E3C2AF42617B8AE9F0296D|sigW regulon]
additional information
A [protein|search|ncRNA] is predicted between '[protein|search|fosB]' and '[protein|search|lexA]' [PubMed|20525796]
Biological materials
Mutant
MGNA-B387 (yndN::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1386 NBRP B. subtilis, Japan]
BKE17840 ([gene|92E4F908B7CDE64743796CCD3188FE6BB5288365|fosB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE17840 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACAAATCATTCCCCCCTTG, downstream forward: _UP4_TGATAGCACAACCATATTTC
BKK17840 ([gene|92E4F908B7CDE64743796CCD3188FE6BB5288365|fosB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK17840 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACAAATCATTCCCCCCTTG, downstream forward: _UP4_TGATAGCACAACCATATTTC
References
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Time of last update: 2025-04-03 15:53:49
Author of last update: Melvin.boenninger