yloH
168
omega subunit of [wiki|RNA polymerase]
locus
BSU_15690
Molecular weight
7.62 kDa
pI
5.51
function
unknown
product
omega subunit of [wiki|RNA polymerase]
essential
no
ec
2.7.7.6
synonyms
yloH, rpoZ
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1758 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,642,567 1,642,770
The protein
Catalyzed reaction/ biological activity
ribonucleoside 5'-triphosphate + RNA(n) --> diphosphate + RNA(n+1) (according to UniProt)
Protein family
[wiki|RNA polymerase] subunit omega family (single member, according to UniProt)
Structure
[PDB|6WVJ] (RNA polymerase elongation complex, [protein|5996A5C25E108A3C4562686BF34A59CB14FD56EB|rpoA]-[protein|EC32328548BFB59D9026ACE351C946DBBC0932BC|rpoB]-[protein|BC8B37355E6FADBA5F4636C3879E99003B0F3E84|rpoC]-[protein|921933B6B893083F151AABDEDCBC65F2E55677BE|yloH]) [pubmed|33339820]
[PDB|5UH5] (transcription initiation complex from Mycobacterium tuberculosis, 37% identity, aa 1- 52) [pubmed|28392175]
[AF|O35011]
[wiki|Localization]
closely associated with [wiki|RNA polymerase] involved in transcribing both mRNA and rRNA operons [Pubmed|20724389]
Expression and Regulation
Operons
genes
[gene|A57D2C1536F3E93CD687C28C59FF297355CAB303|yloC]-[gene|6AF1CB8998BE9C71DF4F1201A7F74FF7E75CB799|remA]-[gene|1BC994DE60A7BB35DEDD7154581A396D29AA94A7|gmk]-[gene|921933B6B893083F151AABDEDCBC65F2E55677BE|yloH]
description
[pubmed|22383849]
regulation
expressed during vegetative growth and early during sporulation in the forespore ([protein|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF]) [Pubmed|23396918]
sigma factors
[protein|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF]: sigma factor, [Pubmed|23396918], in [regulon|protein:CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF regulon]
genes
[gene|A57D2C1536F3E93CD687C28C59FF297355CAB303|yloC]-[gene|6AF1CB8998BE9C71DF4F1201A7F74FF7E75CB799|remA]-[gene|1BC994DE60A7BB35DEDD7154581A396D29AA94A7|gmk]-[gene|921933B6B893083F151AABDEDCBC65F2E55677BE|yloH]-[gene|2B67C63442F28F6BCBA3BA6DE4B563C73E8DF16C|coaBC]-[gene|AF5ADDA2A98EC18BB72A81AA0336E639C0D1F430|priA]-[gene|3D41FB608DB70B9482312A1BBCCDBDA7FB713AFA|defA]-[gene|06971E9AAB033E2878914A76645F99E97CE8A90A|fmt]-[gene|1370D8783450D538C71E3DE8EA5B37DFEE073FF0|yloM]-[gene|5DEBD84E5937DB8B7F29C729FAA0076DF86A5451|yloN]
description
[pubmed|22383849]
genes
[gene|7821A09DADC6EAF589A882F05CC34BE900E06F2A|yloB]-[gene|A57D2C1536F3E93CD687C28C59FF297355CAB303|yloC]-[gene|6AF1CB8998BE9C71DF4F1201A7F74FF7E75CB799|remA]-[gene|1BC994DE60A7BB35DEDD7154581A396D29AA94A7|gmk]-[gene|921933B6B893083F151AABDEDCBC65F2E55677BE|yloH]
description
[pubmed|22383849]
regulation
expressed during sporulation in the mother cell [pubmed|12161109]
Biological materials
Mutant
BKE15690 ([gene|921933B6B893083F151AABDEDCBC65F2E55677BE|yloH]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE15690 BGSC], [Pubmed|28189581], upstream reverse: _UP1_ATCAATTGACGGATCTAACA, downstream forward: _UP4_TAGTAGCACAAGTAGCAACC
BKK15690 ([gene|921933B6B893083F151AABDEDCBC65F2E55677BE|yloH]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK15690 BGSC], [Pubmed|28189581], upstream reverse: _UP1_ATCAATTGACGGATCTAACA, downstream forward: _UP4_TAGTAGCACAAGTAGCAACC
References
Reviews
Original Publications
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Time of last update: 2025-03-17 08:43:36
Author of last update: Jstuelk