ntdR
168
transcription activator of the [gene|2F850E2DFA6287DB3890243803E06FDE7ACDB10E|ntdA]-[gene|A4DE6C394B64813A732255734758403241FFAC2F|ntdB]-[gene|29DAF5343A42EAD8DB97925FE7D049410F7B7FCA|ntdC]-[gene|ADB476B0B385D9B9CAF02902CE115C8309F67911|glcP] operon
locus
BSU_10560
Molecular weight
37.53 kDa
pI
6.64
function
regulation of the [gene|2F850E2DFA6287DB3890243803E06FDE7ACDB10E|ntdA]-[gene|A4DE6C394B64813A732255734758403241FFAC2F|ntdB]-[gene|29DAF5343A42EAD8DB97925FE7D049410F7B7FCA|ntdC]-[gene|ADB476B0B385D9B9CAF02902CE115C8309F67911|glcP] operon
product
transcriptional regulator ([wiki|LacI family])
essential
no
synonyms
ntdR, yhjM
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1609 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,129,715 1,130,704
The protein
Catalyzed reaction/ biological activity
transcription activation of the [gene|2F850E2DFA6287DB3890243803E06FDE7ACDB10E|ntdA]-[gene|A4DE6C394B64813A732255734758403241FFAC2F|ntdB]-[gene|29DAF5343A42EAD8DB97925FE7D049410F7B7FCA|ntdC]-[gene|ADB476B0B385D9B9CAF02902CE115C8309F67911|glcP] operon [Pubmed|17056753]
Protein family
[wiki|LacI family]
[wiki|Domains]
[wiki|HTH lacI-type domain] (aa 2-56) (according to UniProt)
Structure
[PDB|2HSG] ([protein|search|ccpA ]from B. megaterium, 31% identity) [pubmed|17500051]
[AF|O07567]
Effectors of protein activity
3,3'-neotrehalosadiamine and kanosamine act as inducers [Pubmed|33619155,14612444]
Expression and Regulation
Operons
genes
[gene|9118A36CD30E7C99697B3659BB04E03BB7EE71D7|ntdR]
description
[Pubmed|14612444]
regulatory mechanism
[protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB]: repression, [Pubmed|20817675], in [regulon|protein:E5110D9C36E8C55AFD1419987B14A53232165F20|abrB regulon]
Biological materials
Mutant
MGNA-A726 (yhjM::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/726 NBRP B. subtilis, Japan]
BKE10560 ([gene|9118A36CD30E7C99697B3659BB04E03BB7EE71D7|ntdR]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE10560 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATTTTCCCTTCCTTAAA, downstream forward: _UP4_TAACGATAGATTTCCCTTTA
BKK10560 ([gene|9118A36CD30E7C99697B3659BB04E03BB7EE71D7|ntdR]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK10560 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATTTTCCCTTCCTTAAA, downstream forward: _UP4_TAACGATAGATTTCCCTTTA
References
Reviews
Original Publications
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Time of last update: 2024-11-09 00:40:29
Author of last update: Jstuelk