sdhB
168
succinate dehydrogenase
locus
BSU_28430
Molecular weight
28.27 kDa
pI
7.99
function
TCA cycle
product
succinate dehydrogenase (iron-sulfur protein)
essential
no
synonyms
sdhB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0479 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,905,571 2,906,332
The protein
Catalyzed reaction/ biological activity
quinone + succinate --> quinol + fumarate (according to UniProt)
Protein family
succinate dehydrogenase/fumarate reductase iron-sulfur protein family (single member, according to UniProt)
[wiki|Domains]
[wiki|4Fe-4S ferredoxin-type domain] (aa 146-174) (according to UniProt)
[wiki|Cofactors]
Fe-S cluster [pubmed|29292548]
Structure
[PDB|1NEK] (''E. coli'') [pubmed|12560550]
[AF|P08066]
Effectors of protein activity
Inhibited by 2-(n-Heptyl)-4-hydroxy-quinoline N-oxide [Pubmed|3910107]
Activated by Cytochrome b558 [Pubmed|6799760]
[wiki|Localization]
attached to the membrane [Pubmed|18763711]
Expression and Regulation
Operons
genes
[gene|81429F7802CD4B1F7DFDB6C900D7DA5ECA6B9F3F|sdhC]-[gene|0E1FAF4B3A967CC3882B3DDB3CA2D01FD70A0F7E|sdhA]-[gene|901F90AFC94CC7140709845333416106D043269D|sdhB]
description
[Pubmed|3036777]
regulation
constitutive
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|2495271], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Other regulations
[protein|CE542AE1A32CCD1ABB259E6159F7A37A8078E189|fsrA]: translation inhibition, [Pubmed|22389480]
Biological materials
Mutant
GP792 ∆([gene|81429F7802CD4B1F7DFDB6C900D7DA5ECA6B9F3F|sdhC]-[gene|0E1FAF4B3A967CC3882B3DDB3CA2D01FD70A0F7E|sdhA]-[gene|901F90AFC94CC7140709845333416106D043269D|sdhB])::''phleo'', available in [wiki|Jörg Stülke]'s lab
GP2342 ∆([gene|81429F7802CD4B1F7DFDB6C900D7DA5ECA6B9F3F|sdhC]-[gene|0E1FAF4B3A967CC3882B3DDB3CA2D01FD70A0F7E|sdhA]-[gene|901F90AFC94CC7140709845333416106D043269D|sdhB])::''kan'', Cre-recombinase is integrated in [gene|8C2DD87E0351BBEE0FD8C0462087CCAD7459AA88|sacA], available in [wiki|Jörg Stülke]'s lab
GP2343 ∆([gene|81429F7802CD4B1F7DFDB6C900D7DA5ECA6B9F3F|sdhC]-[gene|0E1FAF4B3A967CC3882B3DDB3CA2D01FD70A0F7E|sdhA]-[gene|901F90AFC94CC7140709845333416106D043269D|sdhB])::''lox72'', Cre-recombinase is integrated in [gene|8C2DD87E0351BBEE0FD8C0462087CCAD7459AA88|sacA], available in [wiki|Jörg Stülke]'s lab
References
Reviews
Original Publications
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Time of last update: 2024-11-19 15:44:06
Author of last update: Jstuelk