lspA

lspA
168

signal peptidase II

locus
BSU_15450
Molecular weight
17.28 kDa
pI
9.13
Protein length
Gene length
function
protein secretion
product
signal peptidase II
essential
no
ec
3.4.23.36
synonyms
lspA, lsp

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0597 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,616,744  1,617,208
The protein
Catalyzed reaction/ biological activity
Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains (according to UniProt)
Protein family
peptidase A8 family (single member, according to UniProt)
Structure
[PDB|5DIR] (from Pseudomonas aeruginosa, 38% identity), [pubmed|26912896]
[AF|Q45479]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|8FC1A0A6C9975F6C125490FBAAB2A4957210A9F1|lspA]-[gene|C8C2E2F1B739F3D9A2FA6B460998708AAB2DA495|rluD]-[gene|6D9CEDC7737CCFA838EBC142CD735E066C950AD2|pyrR]
description
[Pubmed|22383849]
Open in new tab

[gene|8FC1A0A6C9975F6C125490FBAAB2A4957210A9F1|lspA]→[gene|6D9CEDC7737CCFA838EBC142CD735E066C950AD2|pyrR]

2024-12-12 14:56:05

Jstuelk

70

8de7ab701af29d04cf1775c3714df5244d59efd2

D260A981278938463A8A0903EAC8DF3268BD4008

Biological materials
Mutant
BKE15450 ([gene|8FC1A0A6C9975F6C125490FBAAB2A4957210A9F1|lspA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE15450 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CACAAACGTTCCTCCAGTTT,  downstream forward: _UP4_GGGAAAAAGAAAAAGGAGCA
BKK15450 ([gene|8FC1A0A6C9975F6C125490FBAAB2A4957210A9F1|lspA]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK15450 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CACAAACGTTCCTCCAGTTT,  downstream forward: _UP4_GGGAAAAAGAAAAAGGAGCA
References
Reviews
34410368
Original Publications
9882689,10497172,9880550,26912896

8FC1A0A6C9975F6C125490FBAAB2A4957210A9F1

Page visits: 2907

Time of last update: 2024-12-30 16:21:46

Author of last update: Jstuelk