lspA
168
signal peptidase II
locus
BSU_15450
Molecular weight
17.28 kDa
pI
9.13
function
protein secretion
product
signal peptidase II
essential
no
ec
3.4.23.36
synonyms
lspA, lsp
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0597 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,616,744 1,617,208
The protein
Catalyzed reaction/ biological activity
Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains (according to UniProt)
Protein family
peptidase A8 family (single member, according to UniProt)
Structure
[PDB|5DIR] (from Pseudomonas aeruginosa, 38% identity), [pubmed|26912896]
[AF|Q45479]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|8FC1A0A6C9975F6C125490FBAAB2A4957210A9F1|lspA]-[gene|C8C2E2F1B739F3D9A2FA6B460998708AAB2DA495|rluD]-[gene|6D9CEDC7737CCFA838EBC142CD735E066C950AD2|pyrR]
description
[Pubmed|22383849]
Biological materials
Mutant
BKE15450 ([gene|8FC1A0A6C9975F6C125490FBAAB2A4957210A9F1|lspA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE15450 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACAAACGTTCCTCCAGTTT, downstream forward: _UP4_GGGAAAAAGAAAAAGGAGCA
BKK15450 ([gene|8FC1A0A6C9975F6C125490FBAAB2A4957210A9F1|lspA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK15450 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACAAACGTTCCTCCAGTTT, downstream forward: _UP4_GGGAAAAAGAAAAAGGAGCA
References
Reviews
Original Publications
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Time of last update: 2024-10-14 11:59:19
Author of last update: Jstuelk