spoIIIL
168
component of the [protein|search|SpoIIIA]-[protein|3282D2C25468776881778006F182FCF322C4821D|spoIIQ] trans-envelope complex, required for the activation of [protein|5F24258282F3166B7696B9E9ABC1706E4D06C944|sigG]
locus
BSU_24660
Molecular weight
9.62 kDa
pI
10.58
function
activation of [protein|5F24258282F3166B7696B9E9ABC1706E4D06C944|sigG]
product
component of the [protein|search|SpoIIIA]-[protein|3282D2C25468776881778006F182FCF322C4821D|spoIIQ] trans-envelope complex
essential
no
synonyms
spoIIIL, yqzE
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG5873 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,555,887 2,556,066
Phenotypes of a mutant
reduced [wiki|sporulation] efficiency (14% compared to wild type) [Pubmed|26735940]
the ''[gene|8F3751A3D0910C9BED7FBCE90AFF7FDACFDCBC0B|spoIIIL] [gene|00BDD4E3370DB3A9F4D75FE265A2A8DF05185CCC|spoIIIAH]'' double mutant has a severe [wiki|sporulation] defect (0.001%) [Pubmed|26735940]
The protein
Structure
[AF|O32020]
[wiki|Localization]
forespore [Pubmed|26735940]
Expression and Regulation
Operons
genes
[gene|41DFEF8A6BC7E34A6681C26D92F2B08DC120A957|comGA]-[gene|EA1C841FC77A1994A85E2E0C0A554482C3EC9323|comGB]-[gene|19D76B80386F825109C5FB4A34881D5D20F366DB|comGC]-[gene|D323AEF5AFB4FD2A074ABAB76A39BE26A4C6436F|comGD]-[gene|FF4DB7FDCEB440064E11E65CB0DBFB93FC785CF0|comGE]-[gene|DD266DC0D78B5C5E82EED7CC7F55D0CF8FB4BF7A|comGF]-[gene|89442BFDFBFF264D0C7F12DEA6F8130C55D1F3F8|comGG]-[gene|8F3751A3D0910C9BED7FBCE90AFF7FDACFDCBC0B|spoIIIL]
description
[Pubmed|26735940,2507524]
regulation
expressed early during sporulation in the forespore ([protein|search|SigF]) [Pubmed|26735940]
regulatory mechanism
[protein|08CFA2C72931A75532D4289BC1D18A826DE9F9CA|comK]: activation, [Pubmed|8196543], in [regulon|protein:08CFA2C72931A75532D4289BC1D18A826DE9F9CA|comK regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|2507524], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
[protein|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF]: sigma factor, [Pubmed|26735940], in [regulon|protein:CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF regulon]
additional information
the ''[wiki|comGA]-[wiki|comGB]-[wiki|comGC]-[wiki|comGD]-[wiki|comGE]-[wiki|comGF]-[wiki|comGG]-[protein|search|spoIIIL]'' operon requires [wiki|NusA] for expression [http://www.nature.com/articles/nmicrobiol20157 Reference]
genes
[gene|8F3751A3D0910C9BED7FBCE90AFF7FDACFDCBC0B|spoIIIL]
description
[Pubmed|26735940]
regulation
expressed early during sporulation in the forespore ([protein|search|SigF]) [Pubmed|26735940]
additional information
the ''[wiki|comGA]-[wiki|comGB]-[wiki|comGC]-[wiki|comGD]-[wiki|comGE]-[wiki|comGF]-[wiki|comGG]-[protein|search|spoIIIL]'' operon requires [wiki|NusA] for expression [http://www.nature.com/articles/nmicrobiol20157 Reference]
Biological materials
Mutant
MGNA-C472 (yqzE::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2470 NBRP B. subtilis, Japan]
BKE24660 ([gene|8F3751A3D0910C9BED7FBCE90AFF7FDACFDCBC0B|spoIIIL]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE24660 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACGTGATCACCTCATCATT, downstream forward: _UP4_TAACCGCAAATAAACGAATA
BKK24660 ([gene|8F3751A3D0910C9BED7FBCE90AFF7FDACFDCBC0B|spoIIIL]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK24660 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACGTGATCACCTCATCATT, downstream forward: _UP4_TAACCGCAAATAAACGAATA
References
Reviews
Original Publications
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Time of last update: 2024-10-11 09:26:33
Author of last update: Jstuelk