yabR
168
similar to the C-terminal domain of E. coli polyribonucleotide phosphorylase and to four repeated domains at the N-terminus of E. coli ribosomal protein S1
locus
BSU_00630
Molecular weight
14.05 kDa
pI
10.34
function
unknown
product
unknown
essential
no
synonyms
yabR
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1098 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
69,626 70,012
Phenotypes of a mutant
defective in [category|SW.4.1.4|Swarming] motility [pubmed|35638827]
The protein
Protein family
Peptidase U57 family (together with [protein|A46D07F8F56249A04C5F880120D19F00C9CAE112|yabG]) (according to UniProt)
[wiki|Domains]
[wiki|S1 domain] (aa 4 ... 74) (according to the Interpro database)
Structure
[PDB|2K4K] ([protein|B0908BB4B8B569A7A78BB0B84784FD4C427C598B|yugI], 51% identity from aa 3 ... 91) [pubmed|19152054]
[AF|P37560]
Paralogous protein(s)
[protein|B0908BB4B8B569A7A78BB0B84784FD4C427C598B|yugI], Array
Expression and Regulation
Operons
genes
[gene|D6B1837075ECBEE1FEAC704DDB6795336092897F|yabM]-[gene|52D48F22CB53421EE30970D34B4861E2F8A5893D|yabN]-[gene|B0CB19A3E3E84E12BF42BB050394C8A059A89359|rqcP]-[gene|035B5486A3887FC71ACC0A8FB43ED77DC44E12EA|yabP]-[gene|4DEDB27C0162409571AB4A1BB17CFE400764AE45|shfA]-[gene|FE0E60B875E72AEF5174A89C7AE5556FF59B19D5|divIC]-[gene|8EDB1BCEEE64FDAF1C9054300751FCB420658865|yabR]
description
[Pubmed|11283287]
regulation
expressed during sporulation ([protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]) [Pubmed|11283287]
sigma factors
[protein|081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM]: sigma factor, [Pubmed|18179421], in [regulon|protein:081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM regulon]
[protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]: sigma factor, [Pubmed|15699190,11283287], in [regulon|protein:3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE regulon]
[protein|3D974DD2967C7F8FD4E3C2AF42617B8AE9F0296D|sigW]: sigma factor, [Pubmed|12207695], in [regulon|protein:3D974DD2967C7F8FD4E3C2AF42617B8AE9F0296D|sigW regulon]
[protein|7024E4162A6D827069F882FDEACA696EBC05DD40|sigD]: sigma factor, [Pubmed|26577401], in [regulon|protein:7024E4162A6D827069F882FDEACA696EBC05DD40|sigD regulon]
[protein|E77364F274A520FCCA9F5C9504E317B047BA29E6|sigX]: sigma factor, [Pubmed|12207695], in [regulon|protein:E77364F274A520FCCA9F5C9504E317B047BA29E6|sigX regulon]
genes
[gene|035B5486A3887FC71ACC0A8FB43ED77DC44E12EA|yabP]-[gene|4DEDB27C0162409571AB4A1BB17CFE400764AE45|shfA]-[gene|FE0E60B875E72AEF5174A89C7AE5556FF59B19D5|divIC]-[gene|8EDB1BCEEE64FDAF1C9054300751FCB420658865|yabR]
description
[Pubmed|11283287]
regulation
expressed during sporulation ([protein|search|SigE]) [Pubmed|11283287]
additional information
there are about 50,000 molecules of DivIC per cell [http://www.ncbi.nlm.nih.gov/sites/entrez/9426141 PubMed]
genes
[gene|FE0E60B875E72AEF5174A89C7AE5556FF59B19D5|divIC]-[gene|8EDB1BCEEE64FDAF1C9054300751FCB420658865|yabR]
description
[Pubmed|11283287]
regulation
expressed during sporulation ([protein|search|SigE]) [Pubmed|11283287] and under stress conditions
additional information
there are about 50,000 molecules of DivIC per cell [http://www.ncbi.nlm.nih.gov/sites/entrez/9426141 PubMed]
Biological materials
Mutant
GP3598 (Δ[gene|8EDB1BCEEE64FDAF1C9054300751FCB420658865|yabR]::''kan''), available in [wiki|Jörg Stülke]'s lab
GP3309 (Δ[gene|B0908BB4B8B569A7A78BB0B84784FD4C427C598B|yugI]::''tet'') (Δ[gene|8EDB1BCEEE64FDAF1C9054300751FCB420658865|yabR]::''aphA3''), available in [wiki|Jörg Stülke]'s lab
GP3314 ([gene|search|''yabR-FLAG''] ''spec''), available in [wiki|Jörg Stülke]'s lab
GP3315 ([gene|search|''yabR-His''] ''spec''), available in [wiki|Jörg Stülke]'s lab
MGNA-B919 (yabR::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1918 NBRP B. subtilis, Japan]
BKE00630 ([gene|8EDB1BCEEE64FDAF1C9054300751FCB420658865|yabR]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE00630 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAAAAAAAGTGCTCCTCC, downstream forward: _UP4_TAACTTGCTGCTTTCTATAA
BKK00630 ([gene|8EDB1BCEEE64FDAF1C9054300751FCB420658865|yabR]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK00630 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAAAAAAAGTGCTCCTCC, downstream forward: _UP4_TAACTTGCTGCTTTCTATAA
two-hybrid system
B. pertussis adenylate cyclase-based bacterial two hybrid system ([wiki|BACTH]), available in [wiki|Jörg Stülke]'s lab
lacZ fusion
GP3327 (based on [wiki|pAC5]) available in [wiki|Jörg Stülke]'s lab
References
Reviews
Original Publications
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Time of last update: 2024-12-21 11:07:46
Author of last update: Jstuelk