tdh
168
L-threonine dehydrogenase
locus
BSU_16990
Molecular weight
36.84 kDa
pI
6.06
function
threonine utilization
product
L-threonine dehydrogenase
essential
no
ec
1.1.1.103
synonyms
tdh
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1063 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,770,461 1,771,504
The protein
Catalyzed reaction/ biological activity
L-threonine + NAD+ --> (2S)-2-amino-3-oxobutanoate + H+ + NADH (according to UniProt)
Protein family
[wiki|zinc-containing alcohol dehydrogenase family] (according to UniProt)
[wiki|Cofactors]
NAD+ (according to UniProt)
Structure
[PDB|2DQ4] (from ''Thermus thermophilus'', 47% identity, 63% similarity)
[AF|O31776]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|8E64B62F15B92A2AACD68B913909100AE276D114|tdh]-[gene|1BC05699DEB3A16944FB8305F22976AED75805E8|kbl]
description
[Pubmed|22383849]
Biological materials
Mutant
BKE16990 ([gene|8E64B62F15B92A2AACD68B913909100AE276D114|tdh]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE16990 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTACAATCCTCCTTGAA, downstream forward: _UP4_TTAATTCCATAAAGGGGGAT
BKK16990 ([gene|8E64B62F15B92A2AACD68B913909100AE276D114|tdh]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK16990 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTACAATCCTCCTTGAA, downstream forward: _UP4_TTAATTCCATAAAGGGGGAT
References
Research papers
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Time of last update: 2024-12-21 17:17:11
Author of last update: Jstuelk