acpA
168
acyl carrier protein
locus
BSU_15920
Molecular weight
8.45 kDa
pI
3.59
function
fatty acid biosynthesis
product
acyl carrier protein
essential
yes
ec
null
synonyms
acpA, acpP
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0236 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,665,337 1,665,570
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Protein family
acyl carrier protein (ACP) family (single member, according to UniProt)
[wiki|Domains]
[wiki|Carrier domain] (aa 2-77) (according to UniProt)
Structure
[PDB|1F80] (complex with [protein|200BE4802FCE3C860565B374EAADC9C1FEEF3E49|acpS]) [Pubmed|10997907], [PDB|3EJE] (complex with [protein|8FBC9A1AC108DC99E275D7A27C18C797D3CDB936|bioI]) [Pubmed|18838690], [PDB|1HY8]
[AF|P80643]
[wiki|Localization]
cytoplasm (according to Swiss-Prot), during sporulation in the mother cell [Pubmed|19850612]
Expression and Regulation
Operons
genes
[gene|8D260693D0C69442BCB9F3D8480E8425ACFE34D2|acpA]
description
[Pubmed|19850612]
regulatory mechanism
[protein|FCDE900167AE36377979E0CF7BC33C7F351B95D3|fapR]: repression, [Pubmed|12737802], in [regulon|protein:FCDE900167AE36377979E0CF7BC33C7F351B95D3|fapR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|16932747], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
genes
[gene|FCDE900167AE36377979E0CF7BC33C7F351B95D3|fapR]-[gene|8F5612395EBF90BEF4C80056EECAFC572384E7F8|plsX]-[gene|BB8542A6444564B21FF5DB6E2C75192C6DA2DFB8|fabD]-[gene|439B468A13137000FB42E9389391CB4986FFED84|fabG]-[gene|8D260693D0C69442BCB9F3D8480E8425ACFE34D2|acpA]
description
[Pubmed|19850612]
regulation
''[protein|FCDE900167AE36377979E0CF7BC33C7F351B95D3|fapR]'': repressed in the absence of malonyl-CoA or malonyl-[protein|8D260693D0C69442BCB9F3D8480E8425ACFE34D2|ACP] ([protein|FCDE900167AE36377979E0CF7BC33C7F351B95D3|fapR]) [Pubmed|12737802]
expression is reduced in motile cells as compared to non-motile cells [pubmed|33782055]
regulatory mechanism
[protein|FCDE900167AE36377979E0CF7BC33C7F351B95D3|fapR]: repression, [Pubmed|12737802], in [regulon|protein:FCDE900167AE36377979E0CF7BC33C7F351B95D3|fapR regulon]
[protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|comA]: activation, ([protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|comA]) [Pubmed|16091051], in [regulon|protein:7832489F11F606BCF637EC23BAAB41AD10237EBB|comA regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|16932747], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Expression vectors
pGP2893: expression of Strep-''acpA'' by [wiki|pGP380] in ''B. subtilis'' suitable for [wiki|SPINE], available in [wiki|Jörg Stülke]'s lab
labs
[wiki|Diego de Mendoza], Universidad Nacional de Rosario, Argentine [http://www.ibr.gov.ar/eng/investigacion/demendoza.htm homepage]
References
Reviews
Original Publications
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Time of last update: 2024-12-20 22:39:11
Author of last update: Jstuelk