gsaB
168
glutamate-1-semialdehyde aminotransferase, required for [protein|3054CD45713BBD69C2A528DE24AF6AF37175FD9D|efp] modification
locus
BSU_08710
Molecular weight
46.04 kDa
pI
5.64
function
biosynthesis of heme, modification of [protein|3054CD45713BBD69C2A528DE24AF6AF37175FD9D|efp]
product
glutamate-1-semialdehyde aminotransferase
essential
no
ec
5.4.3.8
synonyms
gsaB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0001 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
942,449 943,738
Phenotypes of a mutant
inactivation suppresses the [category|SW.4.1.4|Swarming] defect of a [gene|248F0805272FED9B38ECBB31E2872BC9EC163CE0|ymfI] mutant [pubmed|29615499]
defective in [category|SW.4.1.4|Swarming] motility [pubmed|35638827]
The protein
Catalyzed reaction/ biological activity
(S)-4-amino-5-oxopentanoate --> 5-aminolevulinate (according to UniProt)
Protein family
[wiki|Class-III pyridoxal-phosphate-dependent aminotransferase family] (according to UniProt)
[wiki|Cofactors]
pyridoxal phosphate (attached to Lys-267) (according to UniProt)
Structure
[PDB|3BS8] ([protein|A54B2C86638D474F5F892003B42C535B5B39A42E|hemL]) [Pubmed|20946885]
[AF|P71084]
Modification
pyridoxal phosphate attached to Lys-267 (according to UniProt)
Paralogous protein(s)
[protein|A54B2C86638D474F5F892003B42C535B5B39A42E|hemL]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|8BB8EECA8ECFA1CC6D46E81250905DBC6D2C503E|gsaB]
description
[pubmed|22383849]
Biological materials
Mutant
BKE08710 ([gene|8BB8EECA8ECFA1CC6D46E81250905DBC6D2C503E|gsaB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE08710 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAGAATAAAAACCTCCTAT, downstream forward: _UP4_TAGAATCAAATACCTTGAAC
BKK08710 ([gene|8BB8EECA8ECFA1CC6D46E81250905DBC6D2C503E|gsaB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK08710 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAGAATAAAAACCTCCTAT, downstream forward: _UP4_TAGAATCAAATACCTTGAAC
References
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Time of last update: 2025-04-01 09:10:48
Author of last update: Jstuelk