alsR

alsR
168

transcriptional activator of the alsS-alsD operon

Locus
BSU_36020
Molecular weight
34.18 kDa
Isoelectric point
7.29
Protein length
302 aaSequenceBlast
Gene length
909 bpSequenceBlast
Function
regulation of acetoin synthesis (alsS-alsD)
Product
transcriptional activator (LysR family)
Essential
no
Synonyms
alsR
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0583 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,711,498  3,712,406
Phenotypes of a mutant
reduced acetoin production PubMed
impaired biofilm development PubMed
The protein
Catalyzed reaction/ biological activity
binds the promoter region of the alsS-alsD operon in the presence of acetate, activates transcription PubMed
Protein family
LysR family (according to UniProt)
Domains
HTH lysR-type domain (aa 1-58) (according to UniProt)
Structure
2H98 (PDB) (from Acinetobacter baylyi, 34% identity)
Q04778 (AlphaFold)
Effectors of protein activity
acetate (2 molecules per molecule of AlsR) acts as co-factor that triggers activity PubMed
Expression and Regulation
Operons
Genes
alsR-ywrK
Description
PubMed
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alsR→ywrK

2025-03-29 00:36:29

Jstuelk

78

0c4c9296f621b434a75faa015427e4c02d6b9b1d

AA138F6CC87F971586EBC682344D0BD8D693627E

Biological materials
Mutant
AMBs3 (spc), available in Jörg Stülke's lab
1A978 ( alsR::cat), PubMed, available at BGSC
BKE36020 (alsR::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTCAATATGCATTCCTTT,  downstream forward: _UP4_TGAACAATACTTGCAATCTC
BKK36020 (alsR::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTCAATATGCATTCCTTT,  downstream forward: _UP4_TGAACAATACTTGCAATCTC
Labs working on this gene/protein
Elisabeth Härtig, Braunschweig, Germany Homepage
References
Reviews
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Original Publications
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8BA7714236EBFDBB9987F1DACC9775AD974C743E

Page visits: 5347

Time of last update: 2025-04-11 03:46:28

Author of last update: Melvin.boenninger