brxC
168
monothiol bacilliredoxin, general stress protein
locus
BSU_29760
Molecular weight
12.26 kDa
pI
5.09
function
removal of bacillithiol from oxidized cytosolic proteins
product
monothiol bacilliredoxin
essential
no
synonyms
ytxJ, csb40
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms
This gene is a member of the following regulons
Gene
Coordinates
3,046,757 3,047,083
The protein
Catalyzed reaction/ biological activity
removal of bacilliredoxin from oxidized cytosolic proteins, including the glyceraldehyde 3-phosphate dehydrogenases [protein|EB6512177418B1601C6641FB2DEE99C2CD10E671|gapA] and [protein|C1B89BD3DD27CD566018558D3A7845FB451056F0|gapB] [pubmed|33722570]
Protein family
Trx family
[wiki|Domains]
contains a single conserved Cys residue in a motif (TCPIS) reminiscent of that found in monothiol glutaredoxins [Pubmed|20308541]
Structure
[PDB|3IV4] (from Staphylococcus aureus, 41% identity)
[AF|P39914]
Modification
phosphorylation on (Thr-93 OR Ser-94 OR Ser-96 OR Thr-99) [Pubmed|17218307]
Expression and Regulation
Operons
genes
[gene|00A42FDB559BE2647CD682180420A435E2E7035F|facZ]-[gene|43BF293F735ED783D36F33AA4701D57F2AED6657|ytxH]-[gene|8B4E1D087B75B5E77BCB60FF3465270CEB72B028|brxC]
description
[Pubmed|8733232]
regulation
induced by stress ([protein|search|SigB]) [Pubmed|8733232,11544224]
sigma factors
[protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]: sigma factor, [Pubmed|8733232,11544224], in [regulon|protein:580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB regulon]
[protein|DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|sigH]: sigma factor, [Pubmed|8733232], in [regulon|protein:DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|sigH regulon]
Biological materials
Mutant
MGNA-B527 (ytxJ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1526 NBRP B. subtilis, Japan]
BKE29760 ([gene|8B4E1D087B75B5E77BCB60FF3465270CEB72B028|brxC]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE29760 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGACTCAAGCTCTTCCTT, downstream forward: _UP4_TAGAAAAAAGCGTCCAGATA
BKK29760 ([gene|8B4E1D087B75B5E77BCB60FF3465270CEB72B028|brxC]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK29760 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGACTCAAGCTCTTCCTT, downstream forward: _UP4_TAGAAAAAAGCGTCCAGATA
References
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Time of last update: 2025-02-03 01:37:14
Author of last update: Jstuelk