codV
168
site-specific integrase/recombinase, partitioning of the terminus region after replication
locus
BSU_16140
Molecular weight
35.19 kDa
pI
9.31
function
chromosome partitioning
product
site-specific integrase/recombinase
essential
no
synonyms
codV
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG4974 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,687,187 1,688,101
The protein
Catalyzed reaction/ biological activity
resolution of chromosome dimers by site specific recombination at the dif site (located close to the terminus region on the chromosome)
Protein family
[wiki|phage integrase family] (according to UniProt)
Structure
[PDB|1A0P] (from ''E. coli'', 39% identity, complex with [protein|301568A5255A31538F52C46D7711EDAB2BD9CE90|xerD]) [Pubmed|9311978]
[AF|P39776]
Paralogous protein(s)
[protein|301568A5255A31538F52C46D7711EDAB2BD9CE90|xerD]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
assembles on the chromosome at the dif site throughout the cell cycle [Pubmed|21239579]
Expression and Regulation
Operons
genes
[gene|B6062575849EA65BB7B44A9723676885799E2759|trmFO]-[gene|89746E312F20C81BE3CFDFCE7D99B01C375C198B|codV]-[gene|F6B748621B312E0B5A0A0782F3944C3E8112D7A8|clpQ]-[gene|2A5A080273CB7698DFABB147F4143E90BBCA3B01|clpY]-[gene|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY]
description
[Pubmed|22383849]
regulation
repressed during growth in the presence of branched chain amino acids ([protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY]) [Pubmed|11331605]
regulatory mechanism
[protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY]: repression, [Pubmed|11331605], in [regulon|protein:90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|7783641], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
additional information
the intracellular concentration of CodY is about 2.5 myM (according to [PubMed|20408793])
Biological materials
Mutant
1A794 ( ''codV''::''kan''), [Pubmed|10498718], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A794&Search=1A794 BGSC]
BKE16140 ([gene|89746E312F20C81BE3CFDFCE7D99B01C375C198B|codV]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE16140 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGCCTAATACCTCCCCAG, downstream forward: _UP4_AAGAAAAATTAAAGGAGGCC
BKK16140 ([gene|89746E312F20C81BE3CFDFCE7D99B01C375C198B|codV]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK16140 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGCCTAATACCTCCCCAG, downstream forward: _UP4_AAGAAAAATTAAAGGAGGCC
References
Reviews
Original Publications
Page visits: 3276
Time of last update: 2024-12-21 14:10:07
Author of last update: Jstuelk