bmrU
168
general stress protein, multidrug resistance protein, similar to diacylglycerol kinase
locus
BSU_24000
Molecular weight
32.31 kDa
pI
5.39
function
multidrug resistance
product
multidrug resistance protein
essential
no
ec
null
synonyms
bmrU
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1597 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,493,662 2,494,555
The protein
Protein family
diacylglycerol/lipid kinase family (with [protein|943294ACA74067A8549056699E08DF5B82337976|dgkB] and [protein|ED4C1EA16FF96DA20F12B972CD2458FA3B49DDA5|ytlR], according to UniProt)
[wiki|Domains]
DAGKc domain (1-132) (according to UniProt)
Structure
[PDB|3S40] (from ''B. anthracis'', 39% identity, 73% similarity)
[AF|P39074]
Paralogous protein(s)
[protein|943294ACA74067A8549056699E08DF5B82337976|dgkB]
Expression and Regulation
Operons
genes
[gene|88AECCE90DC0D6C92C61AB8860A31A830A8DAC42|bmrU]-[gene|ADBC0F194B601F736492E54011E0A68351B5BD39|bmr]-[gene|9F2C1C9A9DB7AA4CBE72D7C94932B69C8EF0565C|bmrR]
description
[Pubmed|10220166]
regulation
''[protein|search|bmrU]'': induced by stress ([protein|search|SigB]) [Pubmed|11544224]
sigma factors
[protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]: sigma factor, [Pubmed|11544224], in [regulon|protein:580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB regulon]
Biological materials
Mutant
BKE24000 ([gene|88AECCE90DC0D6C92C61AB8860A31A830A8DAC42|bmrU]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE24000 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATACAACTGCTCCTTTA, downstream forward: _UP4_TAACTGTCATAAGGCTTTAG
BKK24000 ([gene|88AECCE90DC0D6C92C61AB8860A31A830A8DAC42|bmrU]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK24000 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATACAACTGCTCCTTTA, downstream forward: _UP4_TAACTGTCATAAGGCTTTAG
References
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Time of last update: 2024-12-22 00:18:47
Author of last update: Melvin.boenninger