motA
168
H+-coupled [protein|86C729C7D5ABEE519ADC4A893940600BBB655EF1|motA]-[protein|FE56753D061344B0F10A6523F49C5C7356AA40B6|motB] flagellar stator
locus
BSU_13690
Molecular weight
29.19 kDa
pI
5.01
function
[category|SW.4.1.1|Motility and chemotaxis]
product
flagellar stator subunit
essential
no
synonyms
motA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1291 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,434,433 1,435,245
Phenotypes of a mutant
loss of swimming and [category|SW.4.1.4|Swarming] motility [Pubmed|24296669,35638827]
mucoid phenotype due to the [protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|degU]-P activated overexpression of the ''[gene|86C05126ADBA22BB1771B1FA3D214B2E7A36311E|capB]-[gene|D66994D077D1382B88FF65075E44C2A31089548F|capC]-[gene|A696434A086A428D411CAF45B37CD8F82AC2503F|capA]-[gene|6B61DCE8D27776EBF942621D3AE90F410FD13F37|capE]'' operon and resulting overproduction of poly-gamma-glutamate [Pubmed|24296669]
not essential for pellicle biofilm formation, but mutant is outcompeted by the wild-type strain when competed during pellicle formation [Pubmed|26122431]
The protein
Protein family
motA family (with [protein|3D42584D65D80A1C73F057714647E29FF6BBD58A|motP], according to UniProt)
Structure
[wiki|6YSF] (the [protein|86C729C7D5ABEE519ADC4A893940600BBB655EF1|motA]5-[protein|FE56753D061344B0F10A6523F49C5C7356AA40B6|motB]2 complex from Clostridium sporogenes) [pubmed|32929189]
[AF|P28611]
Effectors of protein activity
the interaction with [protein|C194336ED96FA844FFE9FB43BE59ADC5D6DDB3BE|motI] inhibits [protein|86C729C7D5ABEE519ADC4A893940600BBB655EF1|motA] activity [Pubmed|22821967]
Paralogous protein(s)
[protein|3D42584D65D80A1C73F057714647E29FF6BBD58A|motP]
[wiki|Localization]
anchored to the cell wall, extending through the cell membrane [pubmed|29196522]
Expression and Regulation
Operons
genes
[gene|86C729C7D5ABEE519ADC4A893940600BBB655EF1|motA]-[gene|FE56753D061344B0F10A6523F49C5C7356AA40B6|motB]
description
[Pubmed|6313226]
sigma factors
[protein|7024E4162A6D827069F882FDEACA696EBC05DD40|sigD]: sigma factor, [Pubmed|6313226], in [regulon|protein:7024E4162A6D827069F882FDEACA696EBC05DD40|sigD regulon]
Biological materials
Mutant
1A631 ( ''motA''::''erm''), [Pubmed|3015878], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A631&Search=1A631 BGSC]
1A923 ( ''motA''::''erm''), [Pubmed|12813063], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A923&Search=1A923 BGSC]
DS7498 (marker-less in NCIB3610) [Pubmed|24296669]
BKE13690 ([gene|86C729C7D5ABEE519ADC4A893940600BBB655EF1|motA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE13690 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAGTTTTCACCAAATCCT, downstream forward: _UP4_TTTGCAGAACAAGGAGAGGC
BKK13690 ([gene|86C729C7D5ABEE519ADC4A893940600BBB655EF1|motA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK13690 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAGTTTTCACCAAATCCT, downstream forward: _UP4_TTTGCAGAACAAGGAGAGGC
References
Reviews
Original Publications
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Time of last update: 2024-12-21 14:43:58
Author of last update: Jstuelk