ohrA
168
peroxiredoxin , protects the cell against organic peroxides
locus
BSU_13140
Molecular weight
14.73 kDa
pI
5.06
function
organic peroxide resistance
product
peroxiredoxin
essential
no
synonyms
ohrA, yklA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1764 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,380,978 1,381,403
The protein
Protein family
osmC/ohr family (with [protein|C36DD4B670D803C5700428F62E6CA7ED127E4B41|ohrB] and [protein|0785B4C70C3DD00EFB8BCDD91EF4F98EF4372186|ymaD], according to UniProt)
Structure
[PDB|2BJO] ([protein|C36DD4B670D803C5700428F62E6CA7ED127E4B41|ohrB], 51% identity) [pubmed|18084074]
[AF|O34762]
Paralogous protein(s)
[protein|C36DD4B670D803C5700428F62E6CA7ED127E4B41|ohrB]
Expression and Regulation
Operons
genes
[gene|869E46AECF6249610F8541E403D834284B62171D|ohrA]
description
[Pubmed|9696771]
regulation
induced by organic peroxides ([protein|search|OhrR]) [Pubmed|11418552]
regulatory mechanism
[protein|7A3A8AF7728474204396BB7A548F747D28E6FAC7|ohrR]: repression, [Pubmed|11418552], in [regulon|protein:7A3A8AF7728474204396BB7A548F747D28E6FAC7|ohrR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|9696771], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
GP1727 [gene|869E46AECF6249610F8541E403D834284B62171D|ohrA]::tet trpC2 available in [wiki|Jörg Stülke]'s lab
MGNA-A749 (yklA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/749 NBRP B. subtilis, Japan]
BKE13140 ([gene|869E46AECF6249610F8541E403D834284B62171D|ohrA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE13140 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTTTCATTCCCCCAATA, downstream forward: _UP4_TAAATAAAAAGAGGATGCCT
BKK13140 ([gene|869E46AECF6249610F8541E403D834284B62171D|ohrA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK13140 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTTTCATTCCCCCAATA, downstream forward: _UP4_TAAATAAAAAGAGGATGCCT
References
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Time of last update: 2025-04-08 01:47:52
Author of last update: Melvin.boenninger