tagD

tagD
168

glycerol-3-phosphate cytidylyltransferase

locus
BSU_35740
Molecular weight
15.13 kDa
pI
5.67
Protein length
Gene length
function
biosynthesis of teichoic acid
product
glycerol-3-phosphate cytidylyltransferase
essential
yes
ec
2.7.7.39
synonyms
tagD

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0615 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,680,581  3,680,970
Phenotypes of a mutant
essential [Pubmed|12682299]
knockdown of expression results in loss of [category|SW.5.2.1|ICEBs1] conjugation (both in donor and recipient cells) [pubmed|35490406]
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The protein
Catalyzed reaction/ biological activity
CTP + H+ + sn-glycerol 3-phosphate --> CDP-glycerol + diphosphate (according to UniProt)
Protein family
cytidylyltransferase family (with [protein|CF9633F769263C6D16EE778F6BD2ECF1995F512A|ispD] and [protein|B25AE6979AF12628780C4489FFED966C6B31968A|yfnH], according to UniProt)
Structure
[PDB|1N1D] (complex with CDP-glycerol) [Pubmed|10508782], [PDB|1COZ]
[AF|P27623]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|8620DA76A1953D7ACDFA7E46ED81EF1A0D97999C|tagD]-[gene|88028A5F3520CB6DAB014412974EB59CC5D226DD|tagE]-[gene|E730E41546298960A4B907FCB7F36C495AA9602B|tagF]-[gene|6795F1703416DCD04E51C177F1C9FE45E73ABAEF|tagG]-[gene|4D3C316965834130BB378CBD1265CFA13F086C7A|tagH]
description
[Pubmed|22383849]
regulation
repressed by phosphate ([protein|search|PhoP]) [Pubmed|9457886]
regulatory mechanism
[protein|638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|phoP]: repression, [Pubmed|9457886], in [regulon|protein:638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|phoP regulon]
[protein|7F340423A34CE40D1F1AA8D373F7C4B859A6496D|walR]: activation, [Pubmed|12950927], in [regulon|protein:7F340423A34CE40D1F1AA8D373F7C4B859A6496D|walR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|7581998], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
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[gene|8620DA76A1953D7ACDFA7E46ED81EF1A0D97999C|tagD]→[gene|4D3C316965834130BB378CBD1265CFA13F086C7A|tagH]

2024-07-07 07:57:24

ghost

90

e797c9b66e258ab8a27376a26baf3e7706d9d053

A1B4C37B759F5A78B84FD9CDC6E9EF59D209E09A

References
Reviews
24024634
Original Publications
9683503,9457886,11673441,10508782,2507871,12950927,7581998,20525796,22383849,35490406

8620DA76A1953D7ACDFA7E46ED81EF1A0D97999C

Page visits: 3222

Time of last update: 2024-07-14 22:58:06

Author of last update: Jstuelk