dtd

dtd
168

D-aminoacyl-tRNA deacylase

locus
BSU_27590
Molecular weight
14.35 kDa
pI
4.35
Protein length
Gene length
function
prevention of misincorporation of D-amino acids into proteins
product
D-aminoacyl-tRNA deacylase
essential
no
synonyms
dtd, yrvI

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1490 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,820,077  2,820,475
Phenotypes of a mutant
D-amino acids are toxic [Pubmed|24097941]
due to a mutation, the protein is not expressed in standard strains such as 168 and NCIB3610 [Pubmed|24097941]
The protein
Protein family
DTD family (single member, according to UniProt)
Structure
[PDB|2DBO] (from Aquifex aeolicus, 55% identity)
[AF|O32042]
Additional information
due to a mutation, the protein is not expressed in standard strains such as 168 and NCIB3610 [Pubmed|24097941]
Expression and Regulation
Operons
genes
[gene|CEE73284EFC0DBE8870CE0B474922DED79475A57|rel]-[gene|860F8A7D054BF483D43B4659732F5A6D30DACBD9|dtd]
description
[Pubmed|9383190]
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[gene|CEE73284EFC0DBE8870CE0B474922DED79475A57|rel]→[gene|860F8A7D054BF483D43B4659732F5A6D30DACBD9|dtd]

2024-10-02 09:25:25

ghost

134

7fb856c2e6ff2d9f5d93b5e8a011814bac480391

9BB1F2AB2B529AE2E3EB57A7D15916559B86340F

Biological materials
Mutant
MGNA-A825 (yrvI::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/825 NBRP B. subtilis, Japan]
BKE27590 ([gene|860F8A7D054BF483D43B4659732F5A6D30DACBD9|dtd]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE27590 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CACTGTAACGCTTGCTTCTG,  downstream forward: _UP4_TAAAAAAAGCTGCCAAAAGG
BKK27590 ([gene|860F8A7D054BF483D43B4659732F5A6D30DACBD9|dtd]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK27590 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CACTGTAACGCTTGCTTCTG,  downstream forward: _UP4_TAAAAAAAGCTGCCAAAAGG
References
9383190,24097941,14527667,15292242

860F8A7D054BF483D43B4659732F5A6D30DACBD9

Page visits: 3905

Time of last update: 2024-10-01 09:39:40

Author of last update: Melvin.boenninger