dtd
168
D-aminoacyl-tRNA deacylase
locus
BSU_27590
Molecular weight
14.35 kDa
pI
4.35
function
prevention of misincorporation of D-amino acids into proteins
product
D-aminoacyl-tRNA deacylase
essential
no
synonyms
dtd, yrvI
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1490 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,820,077 2,820,475
Phenotypes of a mutant
D-amino acids are toxic [Pubmed|24097941]
due to a mutation, the protein is not expressed in standard strains such as 168 and NCIB3610 [Pubmed|24097941]
The protein
Protein family
DTD family (single member, according to UniProt)
Structure
[PDB|2DBO] (from Aquifex aeolicus, 55% identity)
[AF|O32042]
Additional information
due to a mutation, the protein is not expressed in standard strains such as 168 and NCIB3610 [Pubmed|24097941]
Expression and Regulation
Operons
genes
[gene|CEE73284EFC0DBE8870CE0B474922DED79475A57|rel]-[gene|860F8A7D054BF483D43B4659732F5A6D30DACBD9|dtd]
description
[Pubmed|9383190]
Biological materials
Mutant
MGNA-A825 (yrvI::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/825 NBRP B. subtilis, Japan]
BKE27590 ([gene|860F8A7D054BF483D43B4659732F5A6D30DACBD9|dtd]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE27590 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACTGTAACGCTTGCTTCTG, downstream forward: _UP4_TAAAAAAAGCTGCCAAAAGG
BKK27590 ([gene|860F8A7D054BF483D43B4659732F5A6D30DACBD9|dtd]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK27590 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACTGTAACGCTTGCTTCTG, downstream forward: _UP4_TAAAAAAAGCTGCCAAAAGG
References
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Time of last update: 2024-12-21 14:32:36
Author of last update: Melvin.boenninger