cmpA
168
cortex morphogenic protein A, checkpoint protein, orchestrates spore coat and cortex morphogenesis
locus
BSU_04785
Molecular weight
4.00 kDa
function
represses cortex assembly until the successful initiation of spore coat assembly
product
cortex morphogenic protein A, adapter protein targeting [protein|A25C1530DA7BB007A288E525404E9F775E219FE8|spoIVA] for degradation by [protein|search|ClpXP] upon spore envelope defects
synonyms
cmpA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms
This gene is a member of the following regulons
Gene
Coordinates
525,021 → 528,076
Phenotypes of a mutant
quicker progressing through the [wiki|sporulation ] cycle [Pubmed|22463703]
overexpression of CmpA results in heat-sensitive sporulation [Pubmed|22463703,26387458], this can be suppressed by mutations in ''[gene|CB06A70DE7462CEB7AF5D8C28943C878DD56DE1A|clpP]'' and ''[gene|297F53DAD3351E0C55108DD2C93B78FFB174438C|clpX]'' [Pubmed|26387458]
The protein
Catalyzed reaction/ biological activity
orchestrates spore coat and cortex assembly [Pubmed|22463703]
represses cortex assembly until spore coat assembly successfully initiates [Pubmed|22463703]
[wiki|Interactions]
[protein|297F53DAD3351E0C55108DD2C93B78FFB174438C|clpX]-[protein|85DE3CB6CDA61C141C6030367C0A13BB642160B9|cmpA] (for [protein|297F53DAD3351E0C55108DD2C93B78FFB174438C|clpX]-[protein|CB06A70DE7462CEB7AF5D8C28943C878DD56DE1A|clpP]-dependent degradation of [protein|A25C1530DA7BB007A288E525404E9F775E219FE8|spoIVA]) [Pubmed|26387458]
[protein|85DE3CB6CDA61C141C6030367C0A13BB642160B9|cmpA]-[protein|A25C1530DA7BB007A288E525404E9F775E219FE8|spoIVA] (for [protein|297F53DAD3351E0C55108DD2C93B78FFB174438C|clpX]-[protein|CB06A70DE7462CEB7AF5D8C28943C878DD56DE1A|clpP]-dependent degradation of [protein|A25C1530DA7BB007A288E525404E9F775E219FE8|spoIVA]) [Pubmed|26387458]
[wiki|Localization]
surface of the developing spore, this depends on a functional [protein|A25C1530DA7BB007A288E525404E9F775E219FE8|spoIVA] [Pubmed|22463703,26387458]
Expression and Regulation
Operons
genes
[gene|85DE3CB6CDA61C141C6030367C0A13BB642160B9|cmpA]
description
[Pubmed|22463703,20709900]
regulation
expressed in mother cell during [wiki|sporulation ] ([protein|search|SigE], [wiki|SpoIIID]) [Pubmed|22463703]
regulatory mechanism
[protein|90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397|spoIIID]: activation, [Pubmed|22463703], in [regulon|protein:90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397|spoIIID regulon]
sigma factors
[protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]: sigma factor, [Pubmed|22463703], in [regulon|protein:3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE regulon]
References
Reviews
Original Publications
Page visits: 2423
Time of last update: 2024-12-20 15:27:48
Author of last update: Christoph.elfmann