ytpA
168
phospholipase (annotated as a bacilysocin synthase)
locus
BSU_30510
Molecular weight
29.42 kDa
pI
6.77
function
lipid degradation
product
phospholipase
essential
no
synonyms
ytpA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG2267 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,122,662 3,123,441
The protein
Catalyzed reaction/ biological activity
cleaves fatty acids from the 2 position of phosphatidylglycerol [Pubmed|11796336]
Protein family
[wiki|AB hydrolase superfamily] (according to UniProt)
[wiki|Domains]
3 [wiki|AB hydrolase-1 domain]s (aa 37-52, aa 84-97, aa 198-212) (according to InterPro)
Structure
[PDB|3HJU] (human monoglyceride lipase, 30% identity) [Pubmed|19957260]
[AF|O34705]
Expression and Regulation
Operons
genes
[gene|85A653AF4752A61A39F9C42FC791B2D1444886B1|ytpA]-[gene|596C09DD1D9C305B7C49B2F5E90E2C6C33F63D0E|ytpB]
description
[Pubmed|18179421]
regulation
expressed under conditions of salt stress ([protein|081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM]) [pubmed|18179421]
induced by cell wall-inhibiting drugs, such as bacitracin and cefuroxime ([protein|081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM]) [pubmed|38323910]
sigma factors
[protein|081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM]: sigma factor, [Pubmed|18179421], in [regulon|protein:081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM regulon]
Biological materials
Mutant
MGNA-A128 (ytpA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/128 NBRP B. subtilis, Japan]
BKE30510 ([gene|85A653AF4752A61A39F9C42FC791B2D1444886B1|ytpA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE30510 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGATCTTCACCTCATACG, downstream forward: _UP4_TGAACTAGTAGGGGGTGCAT
BKK30510 ([gene|85A653AF4752A61A39F9C42FC791B2D1444886B1|ytpA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK30510 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGATCTTCACCTCATACG, downstream forward: _UP4_TGAACTAGTAGGGGGTGCAT
References
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Time of last update: 2025-01-29 18:56:38
Author of last update: Jstuelk