rsbX

rsbX
168

protein serine phosphatase, feedback PP2C, dephosphorylates RsbS and RsbR

locus
BSU_04740
Molecular weight
22.00 kDa
pI
6.23
Protein length
Gene length
function
control of SigB activity
product
protein serine phosphatase, feedback PP2C
essential
no
ec
3.1.3.3
synonyms
rsbX

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2208 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
523,650  524,249
The protein
Catalyzed reaction/ biological activity
dephosphorylation of [protein|621357D1FB6AC1B0499732EFE226F982B26CE34E|rsbR]-P [Pubmed|15466036] and [protein|841CE7FCA4E84445830CA18F9856F6F30014E3BB|rsbS]-S59-P [Pubmed|8824586,21362065]
H2O + O-phospho-L-(or D)serine --> L-(or D)serine + phosphate (according to UniProt)
[wiki|Domains]
[wiki|PPM-type phosphatase domain] (aa 11-198) (according to UniProt)
Structure
[PDB|3W42], [PDB|3W43] [Pubmed|26057679]
[AF|P17906]
Expression and Regulation
Operons
genes
[gene|621357D1FB6AC1B0499732EFE226F982B26CE34E|rsbR]-[gene|841CE7FCA4E84445830CA18F9856F6F30014E3BB|rsbS]-[gene|ADC52A22950736A0435AEEEC43F7407878786A81|rsbT]-[gene|0B8381D2C724DAA724E4AFC67000F12AD112D13D|rsbU]-[gene|AC64DA463250A090A62E50901EFE653C8F963872|rsbV]-[gene|5AF5F199C5D92E13DE1C56E28948A557E3954CBF|rsbW]-[gene|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]-[gene|8536803BDFB58D43C52961931F609933E49E989D|rsbX]
description
[Pubmed|8002610]
regulation
''[protein|search|rsbV]:'' induced by stress ([protein|search|SigB]) [Pubmed|11544224]
regulatory mechanism
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|20454630], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8002610], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
[protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]: sigma factor, [Pubmed|11544224], in [regulon|protein:580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB regulon]
Open in new tab

[gene|621357D1FB6AC1B0499732EFE226F982B26CE34E|rsbR]→[gene|8536803BDFB58D43C52961931F609933E49E989D|rsbX]

2024-10-09 03:41:18

ghost

169

5f220975cc2493224a8aa0770ee2187c815a2127

3EFC8DC1AC54632D4F2AC30497749AB5CCA3A39F

genes
[gene|AC64DA463250A090A62E50901EFE653C8F963872|rsbV]-[gene|5AF5F199C5D92E13DE1C56E28948A557E3954CBF|rsbW]-[gene|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]-[gene|8536803BDFB58D43C52961931F609933E49E989D|rsbX]
description
[Pubmed|2170324]
regulation
''[protein|search|rsbV]:'' induced by stress ([protein|search|SigB]) [Pubmed|11544224]
Open in new tab

[gene|AC64DA463250A090A62E50901EFE653C8F963872|rsbV]→[gene|8536803BDFB58D43C52961931F609933E49E989D|rsbX]

2024-10-06 01:35:35

ghost

112

c245857c04f8cca86e1f0627f3b25353c582e66e

E6CC0B507AA5819A4C5EBF800596629708A2B80D

Biological materials
Mutant
BKE04740 ([gene|8536803BDFB58D43C52961931F609933E49E989D|rsbX]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE04740 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CTCGTTTTCTTCAACCTGGA,  downstream forward: _UP4_TAAAAAACCAGAAAAAGAAG
BKK04740 ([gene|8536803BDFB58D43C52961931F609933E49E989D|rsbX]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK04740 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CTCGTTTTCTTCAACCTGGA,  downstream forward: _UP4_TAAAAAACCAGAAAAAGAAG
labs
[wiki|Bill Haldenwang], San Antonio, USA
[wiki|Chet Price], Davis, USA [http://foodscience.ucdavis.edu/price_lab/pricelab.html homepage]
References
Reviews
33042030
Original Publications
8002610,8682769,9658013,8002609,10671474,9068644,19923733,11544224,15466036,8824586,23407164,23320651,21362065,26057679

8536803BDFB58D43C52961931F609933E49E989D

Page visits: 4640

Time of last update: 2024-10-11 21:36:02

Author of last update: Jstuelk