fhuD

fhuD
168

hydroxamate siderophore [wiki|ABC transporter ](only ferrichrome) (binding protein)

locus
BSU_33320
Molecular weight
34.27 kDa
pI
9.16
Protein length
Gene length
function
siderophore uptake
product
hydroxamate siderophore [wiki|ABC transporter ](only ferrichrome) (binding protein)
essential
no
synonyms
fhuD

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0614 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,418,474  3,419,421
Phenotypes of a mutant
poor growth with the xenosiderophore ferrichrome as single source of iron [Pubmed|23220087]
The protein
Protein family
[wiki|Bacterial solute-binding protein 8 family] (according to UniProt)
[wiki|Domains]
[wiki|Fe/B12 periplasmic-binding domain] (aa 60-315) (according to UniProt)
Structure
[PDB|4FNA] (from Staphylococcus aureus, 38% identity) [pubmed|24606332]
[AF|P37580]
Paralogous protein(s)
[protein|6F4F7A68701FAC3983AF447F11BC1EAB17D7B07B|yxeB]
[wiki|Localization]
cell membrane (according to Swiss-Prot),  extracellular (signal peptide) [Pubmed|18957862]
Expression and Regulation
Operons
genes
[gene|84CC89907EF39770F5BFACA82A11B04CF76EC5AA|fhuD]
description
[Pubmed|22383849]
regulation
induced by iron starvation (second wave to allow iron scavenging from the environment) ([protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur]) [Pubmed|29133393,12354229]
regulatory mechanism
[protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur]: repression, [pubmed|12354229], in [regulon|protein:F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur regulon]
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[gene|84CC89907EF39770F5BFACA82A11B04CF76EC5AA|fhuD]

2024-09-28 10:19:51

Jstuelk

60

05908b1d1cba06f3b4708ad490a69bc09994f2cd

DB2654F27343CB1AE2DAAF987AB46732ECF36819

Biological materials
Mutant
BKE33320 ([gene|84CC89907EF39770F5BFACA82A11B04CF76EC5AA|fhuD]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE33320 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATATCTCATACCTTCTTTC,  downstream forward: _UP4_TAAACAAAAGAGCCGCCTGC
BKK33320 ([gene|84CC89907EF39770F5BFACA82A11B04CF76EC5AA|fhuD]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK33320 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATATCTCATACCTTCTTTC,  downstream forward: _UP4_TAAACAAAAGAGCCGCCTGC
References
10092453,16672620,12354229,18957862,23220087,29133393,24606332

84CC89907EF39770F5BFACA82A11B04CF76EC5AA

Page visits: 3857

Time of last update: 2024-10-12 16:38:14

Author of last update: Melvin.boenninger