fhuD
168
hydroxamate siderophore [wiki|ABC transporter ](only ferrichrome) (binding protein)
locus
BSU_33320
Molecular weight
34.27 kDa
pI
9.16
function
siderophore uptake
product
hydroxamate siderophore [wiki|ABC transporter ](only ferrichrome) (binding protein)
essential
no
synonyms
fhuD
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0614 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,418,474 3,419,421
Phenotypes of a mutant
poor growth with the xenosiderophore ferrichrome as single source of iron [Pubmed|23220087]
The protein
Protein family
[wiki|Bacterial solute-binding protein 8 family] (according to UniProt)
[wiki|Domains]
[wiki|Fe/B12 periplasmic-binding domain] (aa 60-315) (according to UniProt)
Structure
[PDB|4FNA] (from Staphylococcus aureus, 38% identity) [pubmed|24606332]
[AF|P37580]
Paralogous protein(s)
[protein|6F4F7A68701FAC3983AF447F11BC1EAB17D7B07B|yxeB]
[wiki|Localization]
cell membrane (according to Swiss-Prot), extracellular (signal peptide) [Pubmed|18957862]
Expression and Regulation
Operons
genes
[gene|84CC89907EF39770F5BFACA82A11B04CF76EC5AA|fhuD]
description
[Pubmed|22383849]
regulation
induced by iron starvation (second wave to allow iron scavenging from the environment) ([protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur]) [Pubmed|29133393,12354229]
regulatory mechanism
[protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur]: repression, [pubmed|12354229], in [regulon|protein:F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur regulon]
Biological materials
Mutant
BKE33320 ([gene|84CC89907EF39770F5BFACA82A11B04CF76EC5AA|fhuD]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE33320 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATCTCATACCTTCTTTC, downstream forward: _UP4_TAAACAAAAGAGCCGCCTGC
BKK33320 ([gene|84CC89907EF39770F5BFACA82A11B04CF76EC5AA|fhuD]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK33320 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATCTCATACCTTCTTTC, downstream forward: _UP4_TAAACAAAAGAGCCGCCTGC
References
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Time of last update: 2024-12-04 20:27:15
Author of last update: Jstuelk