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sknR
168
transcriptional repressor ([wiki|Xre family]) of the [gene|16BEDCFFB1671793061ACE4AC528D3B8EB177DC8|yqaF]-[gene|02216407B5EDB98FAF611E22B2323C819B9D58BB|yqdA]-[gene|03DAF537379754763646AF3AF2AD811B107F5302|yqaG]-[gene|F6AB74740776179E77218DB831FEE03773B7353F|yqaH]-[gene|5EA0F507F949D249D5B5B860861BBEB4197E01C5|yqaI]-[gene|CFCCFD8C6420CC1DD076B091AD3D914FC8AB22D5|yqaJ]-[gene|903E11BD2CFF3EE1A831F0F50F91741893C3DAB8|yqaK]-[gene|AB4AF9BD3E16FD72370AFC82CDD1531518053E6F|yqaL]-[gene|F301EA8201BF27BAFAD4F95EC3A580A91B970B06|yqaM]-[gene|3A89444BA25E4940C4197AACBD8B66BC1C65A493|yqaN] operon of the [wiki|skin element]
Molecular weight
13.17 kDa
function
control of prophage gene expression
product
transcriptional repressor ([wiki|Xre family])
Genomic Context
This gene is a member of the following
regulons
Gene
Coordinates
2,698,893 2,699,243
Phenotypes of a mutant
essential in the wild type background (due to overexpression of the toxic proteins [protein|F6AB74740776179E77218DB831FEE03773B7353F|yqaH] and [protein|F301EA8201BF27BAFAD4F95EC3A580A91B970B06|yqaM]) [Pubmed|20889742]
no phenotype if deleted with the complete [wiki|skin element] [Pubmed|20889742]
The protein
Catalyzed reaction/ biological activity
binds the yqaF promoter region to repress transcription of the ''[gene|16BEDCFFB1671793061ACE4AC528D3B8EB177DC8|yqaF]-[gene|02216407B5EDB98FAF611E22B2323C819B9D58BB|yqdA]-[gene|03DAF537379754763646AF3AF2AD811B107F5302|yqaG]-[gene|F6AB74740776179E77218DB831FEE03773B7353F|yqaH]-[gene|5EA0F507F949D249D5B5B860861BBEB4197E01C5|yqaI]-[gene|CFCCFD8C6420CC1DD076B091AD3D914FC8AB22D5|yqaJ]-[gene|903E11BD2CFF3EE1A831F0F50F91741893C3DAB8|yqaK]-[gene|AB4AF9BD3E16FD72370AFC82CDD1531518053E6F|yqaL]-[gene|F301EA8201BF27BAFAD4F95EC3A580A91B970B06|yqaM]-[gene|A9AACF8F25A1A80B3AE2A94DFC3A0E09012B55E7|yqzO]-[gene|3A89444BA25E4940C4197AACBD8B66BC1C65A493|yqaN]'' operon [Pubmed|20889742]
Protein family
[wiki|Domains]
[wiki|HTH cro/C1-type domain] (aa 6-60) (according to UniProt)
Structure
Paralogous protein(s)
[protein|71012848B12CB7BCDEEACDAC6AD1966A971F8FAB|yonR], [protein|25F494F32E200FC0FE4C81A05B0F70CB449673EA|xre]
Expression and Regulation
Operons
genes
[gene|846161AE54F170075F2B2133A8D56FE39A5AF8D9|sknR]
description
[Pubmed|22383849]
[gene|846161AE54F170075F2B2133A8D56FE39A5AF8D9|sknR]
2024-10-10 14:21:56
Jstuelk
53
9087bdc79f0dceb0c2b2b03ee7a79b0fac9748df
A824731CF6DCCED57CC88A9BB13CB033FAC144C8
References
