mcpC
168
membrane-bound chemotaxis receptor for proline, methyl-accepting chemotaxis protein
locus
BSU_13950
Molecular weight
71.93 kDa
pI
5.17
function
control of chemotaxis to proline, threonine, glycine, serine, lysine, valine and arginine
product
methyl-accepting chemotaxis protein
essential
no
synonyms
mcpC, prg71
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0840 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,463,628 1,465,595
The protein
Catalyzed reaction/ biological activity
deaminated [protein|8333CD46F704F03A22482CAA98DEFCC945362A10|mcpC] stimulates phosphorylation of [protein|6B3B222E56BF0C95A2371CA5208B5522B44D4689|cheA] [Pubmed|22931217]
responsible for attractant response towards phenol and other aromatics at low (micromolar) concentrations [pubmed|35007157]
[wiki|Domains]
[wiki|Cache domain] (aa 148-225) (according to UniProt)
[wiki|HAMP domain] (aa 298-350) (according to UniProt)
[wiki|Methyl-accepting transducer domain] (aa 369-619) (according to UniProt)
Structure
[PDB|6S1K] (from E. coli, corresponds to aa 279 ... 593, 26% identity) [pubmed|31925330]
[AF|P54576]
Modification
deamination of Gln-609 (by [protein|BE9373BEB682E5F8B0938AAA4ED9B723B357ABAE|cheD]) [Pubmed|22931217], deaminated [protein|8333CD46F704F03A22482CAA98DEFCC945362A10|mcpC] stimulates phosphorylation of [protein|6B3B222E56BF0C95A2371CA5208B5522B44D4689|cheA] [Pubmed|22931217]
Paralogous protein(s)
[protein|E4E1020B799A1B403BDB4847B91B02D64D161AF3|mcpB], [protein|F02E3080214A327E131ECDE0DBC52C57EFDFE2CE|mcpA], [protein|1DE26CDEE952142C1303C822F0E2A63AE09F721B|tlpA], [protein|4CD44AD8FE68516C84889EAA2137828E06B8A30B|tlpB]
[wiki|Localization]
cell membrane [Pubmed|18763711,21515776]
Expression and Regulation
Operons
genes
[gene|8333CD46F704F03A22482CAA98DEFCC945362A10|mcpC]
description
[Pubmed|9353924]
sigma factors
[protein|7024E4162A6D827069F882FDEACA696EBC05DD40|sigD]: sigma factor, [Pubmed|9353924], in [regulon|protein:7024E4162A6D827069F882FDEACA696EBC05DD40|sigD regulon]
additional information
in minimal medium, McpC is present with 2,800 /- 640 molecules per cell [PubMed|21515776]
Biological materials
Mutant
DS180 (''mcpC''::''mls'' in NCIB3610) [Pubmed|12864845]
BKE13950 ([gene|8333CD46F704F03A22482CAA98DEFCC945362A10|mcpC]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE13950 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAACCAATCCCCTCCTAAT, downstream forward: _UP4_TAATCCAATTACATCCCCAA
BKK13950 ([gene|8333CD46F704F03A22482CAA98DEFCC945362A10|mcpC]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK13950 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAACCAATCCCCTCCTAAT, downstream forward: _UP4_TAATCCAATTACATCCCCAA
References
Reviews
Original Publications
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Time of last update: 2025-04-07 14:02:47
Author of last update: Jstuelk