serS
168
seryl-tRNA-synthetase
locus
BSU_00130
Molecular weight
48.68 kDa
pI
5.19
function
translation
product
seryl-tRNA-synthetase
essential
yes
ec
6.1.1.11
synonyms
serS
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0172 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
20,880 22,157
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
ATP + L-serine + tRNA(Ser) --> AMP + diphosphate + L-seryl-tRNA(Ser) (according to UniProt)
Protein family
[wiki|Class-II aminoacyl-tRNA synthetase family] (according to UniProt)
Structure
[PDB|6R1N] (from ''Staphylococcus aureus'', 54.5% identity) [Pubmed|31626547]
[AF|P37464]
[wiki|Localization]
cytoplasm (according to UniProt)
Expression and Regulation
Operons
genes
[gene|82B92D2FB8DB88689D3A8B77FAD2F63FCCA04C7E|serS]
description
[Pubmed|8915527]
regulation
induced by serine limitation ([protein|search|T-box]) [Pubmed|19258532]
regulatory mechanism
T-box: RNA switch, in [regulon|other_regulator:T-box|T-box]
genes
[gene|7C3081BC8D416127A881627EB56C0628359111CF|dacA]-[gene|651D1E534490276B9BE7BFE7B5819176AE09891E|pdxS]-[gene|6F96C10759C1C20B3A6B396E3718F0A9281F100A|pdxT]-[gene|82B92D2FB8DB88689D3A8B77FAD2F63FCCA04C7E|serS]
description
[Pubmed|22383849]
regulation
the leader mRNA is processed upstream of [gene|7C3081BC8D416127A881627EB56C0628359111CF|dacA] by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y], this requires the [protein|EE52DFA35B935E551871D079A9BE877DB2001A3B|ricA]-[protein|6C9A092F38739A3759793EF8B496569CD02C2E3F|ricF]-[protein|EBD15C174A03B7FCDFFE4C5DB5D86E93F1B9CAC4|ricT] complex [Pubmed|29794222]
genes
[gene|651D1E534490276B9BE7BFE7B5819176AE09891E|pdxS]-[gene|6F96C10759C1C20B3A6B396E3718F0A9281F100A|pdxT]-[gene|82B92D2FB8DB88689D3A8B77FAD2F63FCCA04C7E|serS]
description
[Pubmed|22383849]
References
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Time of last update: 2025-01-18 19:00:29
Author of last update: Jstuelk