kdgA

kdgA
168

2-dehydro-3-deoxy-phosphogluconate aldolase

locus
BSU_22100
Molecular weight
20.72 kDa
pI
5.27
Protein length
Gene length
function
utilization of galacturonic acid
product
2-dehydro-3-deoxy-phosphogluconate aldolase
essential
no
ec
4.1.3.16
synonyms
kdgA

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0800 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,323,009  2,323,599
The protein
Catalyzed reaction/ biological activity
4-hydroxy-2-oxoglutarate --> glyoxylate + pyruvate (according to UniProt)
2-dehydro-3-deoxy-6-phospho-D-gluconate --> D-glyceraldehyde 3-phosphate + pyruvate (according to UniProt)
Protein family
KHG/KDPG aldolase family (single member, according to UniProt)
Structure
[PDB|1VLW] (from Thermotoga maritima, 41% identity)
[AF|P50846]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|891A32A19D1353BA566FF121BBCA7B986D31D129|kdgR]-[gene|8A0BB2BE0AAAA7FF834A4549E8E2AF343FB10571|kdgK]-[gene|826BFCE6ED2113BB0510E798C6CDB05C4665E0E2|kdgA]-[gene|EB6F40F8651654E0AB09447C5AD670C35A59F261|kdgT]
description
[Pubmed|9846747]
regulation
induced by galacturonate ([protein|891A32A19D1353BA566FF121BBCA7B986D31D129|kdgR]) [Pubmed|9846747]
regulatory mechanism
[protein|891A32A19D1353BA566FF121BBCA7B986D31D129|kdgR]: repression, [Pubmed|9846747], in [regulon|protein:891A32A19D1353BA566FF121BBCA7B986D31D129|kdgR regulon]
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|9846747], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|9846747], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
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[gene|891A32A19D1353BA566FF121BBCA7B986D31D129|kdgR]→[gene|EB6F40F8651654E0AB09447C5AD670C35A59F261|kdgT]

2024-09-22 00:29:09

Jstuelk

83

a5bed599599ed10a0553e473cf3c537c32010d6c

3F117D89C62E073C1B4EEA2460C1BBFC9A05A5A3

Biological materials
Mutant
BKE22100 ([gene|826BFCE6ED2113BB0510E798C6CDB05C4665E0E2|kdgA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE22100 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_GTTTTCAACGACTTTGGACT,  downstream forward: _UP4_TAAGTGGAATTGTTTTTTCA
BKK22100 ([gene|826BFCE6ED2113BB0510E798C6CDB05C4665E0E2|kdgA]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK22100 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_GTTTTCAACGACTTTGGACT,  downstream forward: _UP4_TAAGTGGAATTGTTTTTTCA
References
9846747

826BFCE6ED2113BB0510E798C6CDB05C4665E0E2

Page visits: 1752

Time of last update: 2024-10-05 20:58:14

Author of last update: Melvin.boenninger