rplT

rplT
168

ribosomal protein bL20

locus
BSU_28850
Molecular weight
13.50 kDa
pI
11.9
Protein length
Gene length
function
translation
product
ribosomal protein L20 (bL20)
essential
yes
synonyms
rplT

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0292 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,952,224  2,952,583
Phenotypes of a mutant
essential [Pubmed|23002217,12682299]
Visit Sartorius.com Visit Sartorius.com
Advertisement
The protein
Catalyzed reaction/ biological activity
excess [protein|803313600B3CEEE742BD6E5D650B94FB2D32B9EF|rplT] binds the untranslated region of the [gene|E27012060B8220E55277A23C20B1BA6DDBBA4AD1|infC]-[gene|7F22743ED669DBCD4089EA2F86B8FFD924F8C2B9|rpmI]-[gene|803313600B3CEEE742BD6E5D650B94FB2D32B9EF|rplT]-[gene|19349FDFE0F9A46FCCAA684B8139E592979DB317|ysdA] operon mRNA to terminate transcription [pubmed|29925569]
Protein family
bacterial [wiki|ribosomal protein] bL20 family (single member, according to UniProt)
Structure
[PDB|3J9W] (the [wiki|ribosome]) [Pubmed|25903689]
[AF|P55873]
[wiki|Localization]
cytosolic large ribosomal subunit (according to UniProt)
Expression and Regulation
Operons
genes
[gene|E27012060B8220E55277A23C20B1BA6DDBBA4AD1|infC]-[gene|7F22743ED669DBCD4089EA2F86B8FFD924F8C2B9|rpmI]-[gene|803313600B3CEEE742BD6E5D650B94FB2D32B9EF|rplT]-[gene|19349FDFE0F9A46FCCAA684B8139E592979DB317|ysdA]
description
[Pubmed|17289755]
regulation
[protein|CEE73284EFC0DBE8870CE0B474922DED79475A57|rel] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
regulatory mechanism
stringent response: negative regulation, in [regulon|other_regulator:stringent response|stringent response]
[protein|803313600B3CEEE742BD6E5D650B94FB2D32B9EF|rplT]: termination, via binding to a [wiki|RNA switch] in the [gene|E27012060B8220E55277A23C20B1BA6DDBBA4AD1|infC] leader region causes transcription termination, in [regulon|protein:803313600B3CEEE742BD6E5D650B94FB2D32B9EF|rplT regulon]
additional information
autorepression of [gene|E27012060B8220E55277A23C20B1BA6DDBBA4AD1|infC]-[gene|7F22743ED669DBCD4089EA2F86B8FFD924F8C2B9|rpmI]-[gene|803313600B3CEEE742BD6E5D650B94FB2D32B9EF|rplT]-[gene|19349FDFE0F9A46FCCAA684B8139E592979DB317|ysdA] expression upon binding of excess [protein|803313600B3CEEE742BD6E5D650B94FB2D32B9EF|rplT] to the untranslated region of the mRNA [Pubmed|29925569,17616982]
expression of [protein|E27012060B8220E55277A23C20B1BA6DDBBA4AD1|IF3 ]is uncoupled from that of [protein|7F22743ED669DBCD4089EA2F86B8FFD924F8C2B9|L35 ]and [protein|803313600B3CEEE742BD6E5D650B94FB2D32B9EF|L20 ]by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y]-dependent mRNA processing [PubMed|21843271]
the [wiki|RNA switch] RNA is degraded by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [pubmed|29794222]
Open in new tab

[gene|E27012060B8220E55277A23C20B1BA6DDBBA4AD1|infC]→[gene|19349FDFE0F9A46FCCAA684B8139E592979DB317|ysdA]

2024-07-08 14:59:05

Jstuelk

97

6ec080dce630885303f3f439404a1624accce660

33D5901765B267FCB4C316CA6BBC47536C5ACFC6

References
36815589,19653700,11948165,17289755,21843271,23002217,23611891,25903689,29925569

803313600B3CEEE742BD6E5D650B94FB2D32B9EF

Page visits: 5382

Time of last update: 2024-07-15 04:33:22

Author of last update: Jstuelk