fecE
168
iron/citrate [wiki|ABC transporter] (permease)
locus
BSU_07500
Molecular weight
35.06 kDa
pI
10.06
function
iron uptake
product
iron/citrate [wiki|ABC transporter] (permease)
essential
no
synonyms
fecE, yfmE
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0609 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
823,716 824,717
The protein
Protein family
[wiki|Binding-protein-dependent transport system permease family] (according to UniProt)
[wiki|FecCD subfamily] (according to UniProt)
Structure
[PDB|4G1U] (from ''Yersinia pestis'', the [protein|BDAA56484E05DA3C1CB0CA09873A365657999679|fecD]-[protein|800EAB1D8617589CCAC68FB874EFCDE4C77962E1|fecE]-[protein|E76640F895261DA34AD2342B54B43D11857AEA9A|fecF] complex, 37% identity) [Pubmed|23142986]
[PDB|4R9U], the ''E. coli'' BtuC-BtuD complex, BtuC shares 35% identity, 66% similarity with YfmE, [Pubmed|25402482]
[AF|O34832]
Paralogous protein(s)
[protein|BDAA56484E05DA3C1CB0CA09873A365657999679|fecD], [protein|EC98685EE0E3CE6CE8DC33409481AE96315279AC|fhuG], [protein|34A7E22B4EF118EF5A76F8CC2DABBB023BC9A2E9|yfhA]
[wiki|Localization]
cell membrane [Pubmed|10092453]
Expression and Regulation
Operons
genes
[gene|569510093E5B69A0368205920A21A81CADF030E9|fecC]-[gene|BDAA56484E05DA3C1CB0CA09873A365657999679|fecD]-[gene|800EAB1D8617589CCAC68FB874EFCDE4C77962E1|fecE]-[gene|E76640F895261DA34AD2342B54B43D11857AEA9A|fecF]
description
[Pubmed|16672620]
regulation
immediately induced upon iron starvation (first wave to allow iron uptake) ([protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur]) [Pubmed|29133393,16672620,12354229]
regulatory mechanism
[protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur]: repression, [Pubmed|16672620,12354229], in [regulon|protein:F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur regulon]
Biological materials
Mutant
MGNA-C245 (yfmE::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2243 NBRP B. subtilis, Japan]
BKE07500 ([gene|800EAB1D8617589CCAC68FB874EFCDE4C77962E1|fecE]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE07500 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTTTTGTTTTCTGGTTGTTT, downstream forward: _UP4_AGGAAACAGTAGGGAGAGGA
BKK07500 ([gene|800EAB1D8617589CCAC68FB874EFCDE4C77962E1|fecE]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK07500 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTTTTGTTTTCTGGTTGTTT, downstream forward: _UP4_AGGAAACAGTAGGGAGAGGA
References
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Time of last update: 2024-10-12 09:24:28
Author of last update: Melvin.boenninger