czcD
168
cation exporter (antiporter), export of zinc in exchange for extracellular K+ and H+
locus
BSU_26650
Molecular weight
34.01 kDa
pI
5.86
function
cation efflux, resistence against Zn, Cu, Co, Ni
product
cation exporter (antiporter)
essential
no
synonyms
czcD, yrdO
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1230 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,723,892 2,724,827
The protein
Catalyzed reaction/ biological activity
antiport of cytoplasmic Zn2+ in exchange for extracellular K+ and H+ [pubmed|12100555]
Protein family
[wiki|Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family] (according to UniProt)
Structure
[AF|O07084]
[wiki|Localization]
cell membrane (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|7FB5BCC16D688465A820F436F657C49625257884|czcD]-[gene|6D6C324675631B5CAB165D6DF72AA45BF3DB6F29|czcO]
description
[Pubmed|15948947]
regulation
induced in the presence of toxic metal ions (Zn(II), Cd(II), Co(II), Ni(II) and Cu(II)) ([protein|search|CzrA]) [Pubmed|15948947]
regulatory mechanism
[protein|6FB1865734C4DE7BE19D3D1A7E0C687B6D7094E1|czrA]: repression, [Pubmed|15948947], in [regulon|protein:6FB1865734C4DE7BE19D3D1A7E0C687B6D7094E1|czrA regulon]
Biological materials
Mutant
BKE26650 ([gene|7FB5BCC16D688465A820F436F657C49625257884|czcD]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE26650 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAAAAAACTCCTCCTTAC, downstream forward: _UP4_TAAATTTTTTATCTAACTTT
BKK26650 ([gene|7FB5BCC16D688465A820F436F657C49625257884|czcD]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK26650 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAAAAAACTCCTCCTTAC, downstream forward: _UP4_TAAATTTTTTATCTAACTTT
References
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Time of last update: 2024-12-31 00:21:52
Author of last update: Jstuelk