dppD
168
dipeptide [wiki|ABC transporter ](ATP-binding protein)
locus
BSU_12950
Molecular weight
36.53 kDa
pI
7.52
function
uptake of dipeptides
product
dipeptide [wiki|ABC transporter ](ATP-binding protein)
essential
no
synonyms
dppD, dciAD
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0444 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,363,141 1,364,148
The protein
Protein family
[wiki|ABC transporter superfamily] (according to UniProt)
[wiki|Domains]
[wiki|ABC transporter domain] (aa 7-256) (according to UniProt)
Structure
[PDB|4FWI] (from Caldanaerobacter subterraneus, 38% identity) [pubmed|23385461]
[AF|P26905]
Paralogous protein(s)
[protein|BB94F5388A0D1FF025E5A88A7E10AE7E4C489E5F|ykfD], [protein|05752B9C4EA7ACD579D65D028B7DF1861F3840CB|oppD], [protein|325BCDCAB4003204294229B7F9F0A5F353D72B54|appD]
[wiki|Localization]
attached to the cell membrane (via [protein|062AE5FB4C778178A7F6833CB8BD9D631E461E89|dppB]-[protein|EDF8D2C49FA5552B24135E12524F9035E1E01473|dppC]) [Pubmed|10092453]
Expression and Regulation
Operons
genes
[gene|9E922F0006DF9E84A8D5B51E9FC35B669872FF90|dppA]-[gene|062AE5FB4C778178A7F6833CB8BD9D631E461E89|dppB]-[gene|EDF8D2C49FA5552B24135E12524F9035E1E01473|dppC]-[gene|7FA72D949B930A3C7FF0391CC6CCC58EEFCA839A|dppD]-[gene|853C570CFB9382449A20BE77B44B4FE44972AA59|dppE]
description
[Pubmed|1766371]
regulation
repressed by glucose (2.9-fold) [Pubmed|12850135]
regulatory mechanism
[protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY]: repression, [Pubmed|7783641], in [regulon|protein:90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|1766371], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
genes
[gene|9E922F0006DF9E84A8D5B51E9FC35B669872FF90|dppA]-[gene|062AE5FB4C778178A7F6833CB8BD9D631E461E89|dppB]-[gene|EDF8D2C49FA5552B24135E12524F9035E1E01473|dppC]-[gene|7FA72D949B930A3C7FF0391CC6CCC58EEFCA839A|dppD]-[gene|853C570CFB9382449A20BE77B44B4FE44972AA59|dppE]-[gene|C4F85F85F0C99A59145961E34B19D3AD03D2BC22|ykfA]-[gene|77EFC47449D8CC17651ED61C41AC605FCEF01270|ykfB]-[gene|D40ECAE51D9E4791C6FAAA25E2E0D0591D9FAA55|ykfC]-[gene|BB94F5388A0D1FF025E5A88A7E10AE7E4C489E5F|ykfD]
description
[pubmed|22383849]
regulatory mechanism
[protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY]: repression, [Pubmed|12618455], in [regulon|protein:90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY regulon]
additional information
[protein|search|translation] is likely to require [protein|3054CD45713BBD69C2A528DE24AF6AF37175FD9D|efp] due to the presence of several consecutive proline residues [PubMed|23239624,23239623]
Biological materials
Mutant
BKE12950 ([gene|7FA72D949B930A3C7FF0391CC6CCC58EEFCA839A|dppD]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE12950 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GACTGACAGAACTTTTTCCA, downstream forward: _UP4_TCAGGAGATGCGAAGGATTG
BKK12950 ([gene|7FA72D949B930A3C7FF0391CC6CCC58EEFCA839A|dppD]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK12950 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GACTGACAGAACTTTTTCCA, downstream forward: _UP4_TCAGGAGATGCGAAGGATTG
References
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Time of last update: 2024-12-30 06:03:08
Author of last update: Jstuelk