gntZ
168
6-phosphogluconate dehydrogenase
locus
BSU_40080
Molecular weight
51.82 kDa
pI
4.76
function
gluconate utilization
product
6-phosphogluconate dehydrogenase
essential
no
ec
1.1.1.44
synonyms
gntZ
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0362 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
4,117,080 4,118,486
The protein
Catalyzed reaction/ biological activity
6-phospho-D-gluconate + NAD+ --> CO2 + D-ribulose 5-phosphate + NADH (according to UniProt)
Protein family
6-phosphogluconate dehydrogenase family (with [protein|C6CB4993032D8C2CC79A06C67925096F0AFE48CB|yqeC] and [protein|61B7C51EB7E74226890010B61D8E41C02189A453|gndA], according to UniProt)
Structure
[PDB|2W8Z] (from Geobacillus stearothermophilus, 58% identity) [pubmed|19407374]
[AF|P12013]
Paralogous protein(s)
[protein|C6CB4993032D8C2CC79A06C67925096F0AFE48CB|yqeC], [protein|61B7C51EB7E74226890010B61D8E41C02189A453|gndA]
Expression and Regulation
Operons
genes
[gene|1C566E54F8EF1A17A365FC49DFDA452AC5D0CA64|gntR]-[gene|72404FA6ECD62AEA3EFDB934DFB8DA581875605C|gntK]-[gene|C6810A4ACD51EB8D14E5B30163348058196266A1|gntP]-[gene|7E7187AA2DC172018A63A7B9CE48124F30311639|gntZ]
description
[pubmed|10746760,3020045]
regulation
induced by gluconate ([protein|search|GntR]) [Pubmed|3020045]
regulatory mechanism
[protein|1C566E54F8EF1A17A365FC49DFDA452AC5D0CA64|gntR]: repression, [Pubmed|3020045], in [regulon|protein:1C566E54F8EF1A17A365FC49DFDA452AC5D0CA64|gntR regulon]
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|10666464], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
[protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB]: activation, [Pubmed|20817675], in [regulon|protein:E5110D9C36E8C55AFD1419987B14A53232165F20|abrB regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|3020045], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
genes
[gene|7E7187AA2DC172018A63A7B9CE48124F30311639|gntZ]
description
[Pubmed|2419835]
regulation
induced by gluconate ([protein|search|GntR]) [Pubmed|3020045]
Biological materials
Mutant
MGNA-B679 (gntZ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1678 NBRP B. subtilis, Japan]
BKE40080 ([gene|7E7187AA2DC172018A63A7B9CE48124F30311639|gntZ]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE40080 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTGTTACAGCTCCTTCT, downstream forward: _UP4_TAACCTGTATTAAAAACACG
BKK40080 ([gene|7E7187AA2DC172018A63A7B9CE48124F30311639|gntZ]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK40080 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTGTTACAGCTCCTTCT, downstream forward: _UP4_TAACCTGTATTAAAAACACG
References
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Time of last update: 2025-01-04 14:12:20
Author of last update: Melvin.boenninger