iolW
168
scyllo-inositol dehydrogenase, general stress protein
locus
BSU_33530
Molecular weight
39.95 kDa
pI
5.46
function
utilization of scyllo-inosose
product
scyllo-inositol dehydrogenase
essential
no
synonyms
iolW, yvaA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0673 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,444,329 3,445,405
The protein
Catalyzed reaction/ biological activity
NADPH-dependent conversion of scyllo-inosose to scyllo-inositol [pubmed|20133360]
NADP+ + scyllo-inositol --> H+ + NADPH + scyllo-inosose (according to UniProt)
Protein family
[wiki|Gfo/Idh/MocA family] (according to UniProt)
[wiki|Cofactors]
NADP+ [pubmed|20133360]
Structure
[PDB|3GFG]
[AF|O32223]
Paralogous protein(s)
[protein|920C5750CB95102B073C32874D512E8D636D2C7D|iolU], [protein|93C1DF93CAFC5AE726523A91A3BA7470017FF6DC|iolG], [protein|942BAE9FA023DFCA06B6D26A856A72F2979E23FA|yrbE], [protein|AA7DCEFB17FD6F9C4F65235E9A247A6EC2242B06|iolX], [protein|03BE6DA854612B3F6741E0E167AB310F0DE96285|yfiI], [protein|29DAF5343A42EAD8DB97925FE7D049410F7B7FCA|ntdC], [protein|484D17480DFAD3667E0EBC6D38854A7546A8DB46|yteT]
Expression and Regulation
Operons
genes
[gene|7DFE74C751A67CCC84579D52005E1399B0A10166|iolW]
description
[pubmed|22383849]
regulation
induced by stress ([protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]) [Pubmed|15805528]
sigma factors
[protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]: sigma factor, [Pubmed|15805528], in [regulon|protein:580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB regulon]
Biological materials
Mutant
MGNA-A443 (iolU::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/443 NBRP B. subtilis, Japan]
BKE33530 ([gene|7DFE74C751A67CCC84579D52005E1399B0A10166|iolW]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE33530 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAACAGAAGTATATACCCTC, downstream forward: _UP4_TAAAACAAAAGCCTCCCCAA
BKK33530 ([gene|7DFE74C751A67CCC84579D52005E1399B0A10166|iolW]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK33530 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAACAGAAGTATATACCCTC, downstream forward: _UP4_TAAAACAAAAGCCTCCCCAA
References
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Time of last update: 2024-12-19 14:01:12
Author of last update: Melvin.boenninger