bpsA
168
type III polyketide synthase
locus
BSU_22050
Molecular weight
40.55 kDa
pI
7.96
function
polyketide synthesis
product
type III polyketide synthase
essential
no
ec
2.3.1.74
synonyms
bpsA, bcsA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG3424 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,316,956 2,318,053
The protein
Catalyzed reaction/ biological activity
synthesis of triketide pyrones from long-chain fatty acyl CoA thioesters as starter substrates and malonyl-CoA as an extender substrate [Pubmed|19465653]
4-coumaroyl-CoA + 2 H+ + 3 malonyl-CoA --> 2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA (according to UniProt)
Protein family
[wiki|thiolase-like superfamily] (according to UniProt)
Structure
[PDB|4JAO] (from Mycobacterium tuberculosis, 34% identity) [pubmed|23615910]
[AF|P54157]
Expression and Regulation
Operons
genes
[gene|7D90F7AF49BAD6A95731BF805991DEBBBCAFA46C|bpsA]-[gene|6BAF5763249305F27326F941A34956396B3F8C99|bpsB]
description
[Pubmed|19465653]
Biological materials
Mutant
MGNA-A875 (bcsA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/875 NBRP B. subtilis, Japan]
BKE22050 (''[gene|7D90F7AF49BAD6A95731BF805991DEBBBCAFA46C|bpsA]''::''erm'', available in the BGSC and in [wiki|Jörg Stülke]'s lab) [pubmed|28189581]
GP1820 (''[gene|7D90F7AF49BAD6A95731BF805991DEBBBCAFA46C|bpsA]''::''erm'', available in [wiki|Jörg Stülke]'s lab)
BKE22050 ([gene|7D90F7AF49BAD6A95731BF805991DEBBBCAFA46C|bpsA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE22050 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGCGATCACCTCTTTGCA, downstream forward: _UP4_AGCTGGGAAAAGGGGGCCTG
BKK22050 ([gene|7D90F7AF49BAD6A95731BF805991DEBBBCAFA46C|bpsA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK22050 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGCGATCACCTCTTTGCA, downstream forward: _UP4_AGCTGGGAAAAGGGGGCCTG
References
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Time of last update: 2024-12-29 00:12:53
Author of last update: Melvin.boenninger