acdA
168
acyl-CoA dehydrogenase
locus
BSU_37170
Molecular weight
41.29 kDa
pI
4.95
function
fatty acid degradation
product
acyl-CoA dehydrogenase
essential
no
synonyms
acdA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1960 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,813,246 3,814,385
The protein
Catalyzed reaction/ biological activity
A + 2,3-saturated acyl-CoA --> 2,3-dehydroacyl-CoA + AH2 (according to UniProt)
Protein family
[wiki|Acyl-CoA dehydrogenase family] (according to UniProt)
[wiki|Cofactors]
FAD (according to UniProt)
Structure
[PDB|2Z1Q] (from ''Thermus thermophilus hb8'', 40% identity, 55% similarity)
[AF|P45867]
Paralogous protein(s)
[protein|B5325CBF1408E2CA227EB462092E209F4C87E797|fadE], [protein|BA28DFBAF88A4994B0541D1FF2187312FDE1FA15|yngJ], [protein|F25CDDEBAFC72036664323619F5197D45E86BE9A|mmgC]
Expression and Regulation
Operons
genes
[gene|DEE0DA15EE9EA27BA8C332204E40D336324A111C|fadF]-[gene|7D89BBB52403BF99416250688EFA90C2BE8EB591|acdA]-[gene|632C661255DD9C2865CB2F9D68A805997A833BCB|rpoE]
description
[Pubmed|17189250]
regulation
repressed in the absence of long-chain fatty acids ([protein|8A8F93BAD0582F712C9EE1C3FE6C04292E91F390|fadR]) [Pubmed|17189250]
regulatory mechanism
[protein|8A8F93BAD0582F712C9EE1C3FE6C04292E91F390|fadR]: repression, [Pubmed|17189250], in [regulon|protein:8A8F93BAD0582F712C9EE1C3FE6C04292E91F390|fadR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|17189250], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
BKE37170 ([gene|7D89BBB52403BF99416250688EFA90C2BE8EB591|acdA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE37170 BGSC], [Pubmed|28189581], upstream reverse: _UP1_ATTCATTGCTTCTCCCCCAT, downstream forward: _UP4_TAACGGAAAACATCTCTCAG
BKK37170 ([gene|7D89BBB52403BF99416250688EFA90C2BE8EB591|acdA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK37170 BGSC], [Pubmed|28189581], upstream reverse: _UP1_ATTCATTGCTTCTCCCCCAT, downstream forward: _UP4_TAACGGAAAACATCTCTCAG
References
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Time of last update: 2024-12-30 19:10:14
Author of last update: Melvin.boenninger