pncB

pncB
168

nicotinamide phosphoribosyltransferase, nicotinate phosphoribosyltransferase

locus
BSU_31750
Molecular weight
56.01 kDa
pI
5.09
Protein length
Gene length
function
NAD salvage and biosynthesis
product
nicotinamide phosphoribosyltransferase
essential
yes
ec
2.4.2.11
synonyms
pncB, yueK

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1488 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,259,403  3,260,875
Phenotypes of a mutant
essential [Pubmed|12682299]
The protein
Catalyzed reaction/ biological activity
5-phospho-α-D-ribose 1-diphosphate + ATP + H2O + nicotinamide --> nicotinamide mononucleotide + ADP + diphosphate + phosphate [https://www.sciencedirect.com/science/article/pii/S1359511324000539#ab0020 paper]
5-phospho-α-D-ribose 1-diphosphate + ATP + H2O + nicotinate --> ADP + diphosphate + nicotinate β-D-ribonucleotide + phosphate (according to UniProt)
Protein family
NAPRTase family (single member, according to UniProt)
Structure
[PDB|2F7F] (from ''Enterococcus faecalis'', 61% identity)
[AF|O32090]
Expression and Regulation
Operons
genes
[gene|26430DCCEC263E7D03A3BBA4E7D636A250C3208B|pncA]-[gene|7CA7ADDBDDE46B0E6522704FD19C0BCF6FA9E058|pncB]
description
[Pubmed|22383849]
Open in new tab

[gene|26430DCCEC263E7D03A3BBA4E7D636A250C3208B|pncA]→[gene|7CA7ADDBDDE46B0E6522704FD19C0BCF6FA9E058|pncB]

2024-10-03 19:12:04

Jstuelk

67

c5c9ff76ca846e3f2d664a2a5d107f68232e724f

3224FCF112021DBE533BF399D23A742E748543C1

genes
[gene|17F2619E74A1604E86ED94E1BEE683D49E437A6C|yueH]-[gene|3918D82756A64E86E96A21ACEB34B0CF992D662D|yueI]-[gene|26430DCCEC263E7D03A3BBA4E7D636A250C3208B|pncA]-[gene|7CA7ADDBDDE46B0E6522704FD19C0BCF6FA9E058|pncB]
description
[Pubmed|22383849]
Open in new tab

[gene|17F2619E74A1604E86ED94E1BEE683D49E437A6C|yueH]→[gene|7CA7ADDBDDE46B0E6522704FD19C0BCF6FA9E058|pncB]

2024-08-28 11:09:47

Jstuelk

52

0485297a8e17297cf873bffb65c41585c1d220bf

B2D23F93CDEBEB6BC09AB1B35C95355662FF0176

Biological materials
Mutant
MGNA-B562 (yueK::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1561 NBRP B. subtilis, Japan]
References
16199587,9274030

7CA7ADDBDDE46B0E6522704FD19C0BCF6FA9E058

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Time of last update: 2024-10-03 06:55:55

Author of last update: Jstuelk