yneA
168
inhibits cell division during SOS response
locus
BSU_17860
Molecular weight
11.75 kDa
pI
4.61
function
inhibits cell division during SOS response
product
checkpoint enforcement protein
essential
no
synonyms
yneA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms
This gene is a member of the following regulons
Gene
Coordinates
1,918,406 1,918,723
Phenotypes of a mutant
increased sensitivity to DNA-damaging agents [Pubmed|23728628]
inactivation allows growth of a [gene|search|whiA ][gene|search|parB ]double mutant [pubmed|29378890]
The protein
Protein family
YneA family (single member, according to UniProt)
[wiki|Domains]
contains a N-acetylglucosamine-polymer-binding [wiki|LysM domain] (aa 38-89) [Pubmed|20400548,18430080]
Structure
[AF|Q45056]
[wiki|Localization]
secreted to the medium (signal peptide) [Pubmed|20400548]
Additional information
the activity can be bypassed by specific variants of [protein|8AB7D225DBEE6BD695A4A8A2384D2C029B571C57|ftsW] [pubmed|34097787]
Expression and Regulation
Operons
genes
[gene|7BF591DCDC9635C605D76135481A8A9DB63EE861|yneA]-[gene|67074435B8FDA85C8ED4D8C4ECE3580C4EDFBF2A|yneB]-[gene|5BFD552F8A467C8D95FABE87CC8C5E7F04114886|ynzC]
description
[Pubmed|12581363]
regulation
induced by DNA damage ([protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|lexA]) [Pubmed|12581363]
regulatory mechanism
[protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|lexA]: repression, [Pubmed|12581363], in [regulon|protein:D267AF38B0CF107042326E9B8F3DD3C9C85840E4|lexA regulon]
additional information
YneA is rapidly degraded by extracellular proteases ([protein|5ED8301B9681FDD5171A9344A971E891493A6558|ctpA]) [PubMed|29979679,20400548]
Biological materials
Mutant
MGNA-B388 (yneA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1387 NBRP B. subtilis, Japan]
BKE17860 ([gene|7BF591DCDC9635C605D76135481A8A9DB63EE861|yneA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE17860 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAACCTCCAACAGGAATG, downstream forward: _UP4_AGATAGAGAGGAAAGAGAGA
BKK17860 ([gene|7BF591DCDC9635C605D76135481A8A9DB63EE861|yneA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK17860 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAACCTCCAACAGGAATG, downstream forward: _UP4_AGATAGAGAGGAAAGAGAGA
References
Reviews
Original Publications
Page visits: 4285
Time of last update: 2025-03-02 18:37:40
Author of last update: Jstuelk