ohrR

ohrR
168

transcription repressor of the ohrA gene

Locus
BSU_13150
Molecular weight
16.86 kDa
Isoelectric point
6.36
Protein length
147 aaSequenceBlast
Gene length
444 bpSequenceBlast
Function
regulation of ohrA expression in response to organic peroxides
Product
transcription repressor (MarR family)
Essential
no
Synonyms
ohrR, ykmA
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1846 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,381,434  1,381,877
The protein
Protein family
MarR family
Domains
HTH marR-type domain (aa 11-141) (according to UniProt)
Structure
1Z91 (PDB) (reduced form),  1Z9C (PDB) (complex with ''ohrA'' promoter)
O34777 (AlphaFold)
Modification
senses organic peroxides and NaOCl, released from DNA upon oxidation of an active site cysteine
S-bacillithiolated by NaOCl and CHP stress on Cys-15, this results in release from the'' ohrA'' promoter PubMed
Localization
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
ohrR
Description
PubMed
Sigma factors
SigA: sigma factor, in sigA regulon
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ohrR

2025-04-10 07:18:21

ghost

85

64f549cb5db21a2b129e973b455a67614a104a95

56B0D78C99D62CA07B3BBE5E51669588D7BCCD0A

Biological materials
Mutant
GP3172 ohrR::kan trpC2 available in Jörg Stülke's lab
MGNA-A750 (ykmA::erm), available at the NBRP B. subtilis, Japan
BKE13150 (ohrR::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTTGTTCACCAACTCTT,  downstream forward: _UP4_TGAGGATGCCTTGTACAGGC
BKK13150 (ohrR::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTTGTTCACCAACTCTT,  downstream forward: _UP4_TGAGGATGCCTTGTACAGGC
Labs working on this gene/protein
John Helmann, Cornell University, USA Homepage
Richard Brennan, Houston, Texas, USA Homepage
References
Reviews
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Original Publications
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7A3A8AF7728474204396BB7A548F747D28E6FAC7

Page visits: 2131

Time of last update: 2025-05-14 20:04:27

Author of last update: Melvin.boenninger