ftsL
168
[wiki|cell division] protein (septum formation), controls together with [protein|B317D7E51824DD70EF84E4D5D7290D601BF4FAB6|ezrA] dynamics of the [protein|41872E2EF00C79918DD077F2EF78F37E24FEB110|ftsZ] ring, part of the [wiki|divisome]
locus
BSU_15150
Molecular weight
12.93 kDa
pI
10.08
function
Z-ring maturation and focusing septal peptidoglycan synthesis
product
[wiki|cell division] protein, member of the [wiki|divisome]
essential
yes
synonyms
ftsL, ylxB, yllD
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG4839 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,581,597 1,581,950
Phenotypes of a mutant
essential [Pubmed|12682299]
depletion results in decondensation of the [protein|41872E2EF00C79918DD077F2EF78F37E24FEB110|ftsZ] ring and lethal filamentation [pubmed|35943250]
The protein
Protein family
FtsL family (single member, according to UniProt)
Structure
[AF|Q07867]
Effectors of protein activity
degraded by [protein|CB50289535EA537F63BADD459BD11AA7759A6658|rasP], stabilized against [protein|CB50289535EA537F63BADD459BD11AA7759A6658|rasP] cleavage by [protein|FE0E60B875E72AEF5174A89C7AE5556FF59B19D5|divIC] [Pubmed|20644139]
[wiki|Localization]
cell membrane (according to UniProt)
localizes to the division site, this depends on [protein|8AB7D225DBEE6BD695A4A8A2384D2C029B571C57|ftsW] [Pubmed|27895631]
Expression and Regulation
Operons
genes
[gene|A7131ACFA0CF5C222237C76E502D4AAD1F9BA3E4|mraZ]-[gene|1F894D6895CE13AA006CFE13A702E46C568F6E79|rsmH]-[gene|79712F4CF884A660C71B45B3397AEFA5C0AFA683|ftsL]-[gene|EBEFF9E0A524DCDA19382E5401B923B805E4C559|pbpB]
description
[Pubmed|8636036,8244929]
regulation
constitutively expressed [Pubmed|15758244]
additional information
FtsL is degraded by [protein|CB50289535EA537F63BADD459BD11AA7759A6658|rasP] [PubMed|17020588]
Biological materials
Mutant
MGNA-B127 (ftsL::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1126 NBRP B. subtilis, Japan]
FLAG-tag construct
GP2004 ''ftsL-3xFLAG ermC'' (based on [wiki|pGP1087]), available in [wiki|Jörg Stülke]'s lab
References
Reviews
Original Publications
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Time of last update: 2024-12-29 01:16:32
Author of last update: Jstuelk